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[摘要]
目的 探讨缩泉胶囊联合琥珀酸索利那新片治疗膀胱过度活动症的临床疗效。方法 选取2015年2月-2017年2月在河南省直第三人民医院进行治疗的膀胱过度活动症患者120例,按照治疗方法的不同分为对照组(60例)和治疗组(60例)。对照组口服琥珀酸索利那新片,5 mg/次,1次/d。治疗组在对照组的基础上口服缩泉胶囊,1.8 g/次,3次/d。两组患者均治疗4周。评价两组患者临床疗效,同时比较治疗前后两组患者膀胱过度运动症状评分表(OABSS)和患者膀胱状况感知量表(PPBC)评分以及相关临床症状变化。结果 治疗后,对照组总有效率为81.67%,显著低于治疗组的96.67%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者OABSS和PPBC评分均显著降低,同组比较差异具有统计学意义(P<0.05),且治疗组评分比对照组降低更明显,两组比较差异具有统计学意义(P<0.05)。治疗后,两组24 h尿急次数、24 h排尿次数、24 h夜尿次数和24 h急迫性尿失禁次数均显著降低,同组比较差异具有统计学意义(P<0.05),且治疗组上述临床症状明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 缩泉胶囊联合琥珀酸索利那新片治疗膀胱过度活动症效果显著,可有效改善临床症状,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical efficacy of Suoquan Capsules combined with Solifenacin Succinate Tablets in treatment of overactive bladder. Methods Patients (120 cases) with overactive bladder in the Third Provincial Hospital of Henan Province from February 2015 to February 2017 were divided into control (60 cases) and treatment (60 cases) groups based on different treatments. Patients in the control group were po administered with Solifenacin Succinate Tablets, 5 mg/time, once daily. Patients in the treatment group were po administered with Suoquan Capsules on the basis of the control group, 1.8 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the change of OABSS and PPBC scores, and adverse reaction in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.67%, which was significantly lower than 96.67% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the OABSS and PPBC scores in two groups were significantly decreased, the difference was statistically significant in the same group (P<0.05). And the scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the frequency of 24 urgent urination, 24 h micturition, 24 h nocturia, and 24 h urge incontinence in two groups was significantly decreased, the difference was statistically significant in the same group (P<0.05). And these clinical symptoms in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Suoquan Capsules combined with Solifenacin Succinate Tablets has significant effect in treatment of overactive bladder, can effectively improve the clinical symptoms, which has a certain clinical application value.
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