目的 探讨注射用还原型谷胱甘肽联合注射用门冬氨酸鸟氨酸治疗婴儿肝炎综合征的临床疗效。方法 选择2015年12月-2016年12月漯河市第一人民医院收治婴的儿肝炎综合征患儿70例作为研究对象，全部患儿随机分为对照组和治疗组，每组各35例。对照组静脉滴注注射用门冬氨酸鸟氨酸，0.5 g加入到5%葡萄糖溶液50 mL中，1次/d。治疗组在对照组基础上静脉滴注注射用还原型谷胱甘肽，0.3 g加入到5%葡萄糖溶液30 mL中，1次/d。两组患儿均连续治疗14 d。观察两组的临床疗效，比较两组生化指标和炎症因子。结果 治疗后，对照组和治疗组的总有效率分别为88.6%、97.1%，两组比较差异有统计学意义（P<0.05）。治疗后，两组丙氨酸氨基转移酶（ALT）、总胆酸（TBA）、总胆红素（TBIL）、直接胆红素（DBIL）和谷氨酰转肽酶（GGT）水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 注射用还原型谷胱甘肽联合注射用门冬氨酸鸟氨酸治疗婴儿肝炎综合征具有较好的临床疗效，能显著降低ALT、TBA、TBIL、DBIL和GGT水平，减轻炎症水平，具有一定的临床推广应用价值。

Objective To study clinical effect of Reduced Glutathione for injection combined with Ornithine Aspartate for injection in treatment of infantile hepatitis syndrome. Methods Children (70 cases) with hepatitis syndrome in Luohe Central Hospital from December 2015 to December 2016 were randomly divided into control and treatment groups, and each group had 35 cases. Patients in the control group were iv administered with Reduced Glutathione for injection, 0.5 g added into 5% glucose solution 50 mL, once daily. Patients in the treatment group were iv administered with Ornithine Aspartate for injection on the basis of the control group, 0.3 g added into 5% glucose solution 30 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and biochemical indexes and inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 88.6% and 97.1%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of ALT, TBA, TBIL, DBIL, and GGT in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of IL-6 and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Reduced Glutathione for injection combined with Ornithine Aspartate for injection has clinical curative effect in treatment of infantile hepatitis syndrome, and can significantly decrease the levels of ALT, TBA, TBIL, DBIL, and GGT, and reduce inflammation levels, which has a certain clinical application value.