[关键词]
[摘要]
目的 探讨金叶败毒颗粒联合热毒宁注射液治疗小儿病毒性肺炎的临床效果。方法 选取陕西省人民医院儿童病院2016年3月-2017年3月收治的小儿病毒性肺炎患者80例,随机分为对照组(40例)和治疗组(40例)。对照组患儿静脉滴注热毒宁注射液,2~5岁患儿,5 mL加入生理盐水100 mL,滴速30~40滴/min,1次/d;6~10岁患儿,10 mL加入生理盐水200 mL,滴速30~60滴/min,1次/d。治疗组患儿在对照组的基础上口服金叶败毒颗粒,10 g/次,3次/d。两组患儿均治疗7 d。评价两组患儿临床疗效,同时比较治疗前后两组患儿临床症状、体征改善情况和临床症状、体征评分以及血清血清白介素(IL)-6、IL-8、肿瘤坏死因子(TNF)-α水平。结果 治疗后,对照组患儿总有效率为72.50%,显著低于治疗组的92.50%,两组比较差异具有统计学意义。治疗后,治疗组退热时间、肺部湿啰音消失时间、咳嗽消失时间和咽痛消失时间均显著短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患儿咳嗽评分、气促评分、体温评分、肺部啰音评分、总评分均显著降低(P<0.05);且治疗组上述评分显著低于对照组(P<0.05)。治疗后,两组IL-6、IL-8、TNF-α炎性指标水平均显著低于治疗前(P<0.05);且与对照组相比,治疗组上述指标降低更明显(P<0.05)。结论 金叶败毒颗粒联合热毒宁注射液治疗小儿病毒性肺炎能有效缓解患者的临床症状、体征,减少炎性反应发生,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To explore the clinical effect of Jinye Baidu Granules combined with Reduning Injection in treatment of children with viral pneumonia. Methods Children (80 cases) with viral pneumonia in Childrens' Hospital of Shaanxi Provincial People's Hospital from March 2016 to March 2017 were randomly divided into control (40 cases) and treatment (40 cases) groups. Children in the control group were iv administered with Reduning Injection, 5 mL added into 100 mL normal saline for 2-5 years old children, the dropping speed was 30-40 drops/min, and 10 mL added into 200 mL normal saline for 6-10 years old children, the dropping speed was 30-60 drops/min, once daily. Children in the treatment group were po administered with Jinye Baidu Granules on the basis of the control group, 10 g/time, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptoms and signs, symptoms and signs scores, serum levels of IL-6, IL-8 and TNF-α in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 72.50%, which was significantly lower than 92.50% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the pyretolysis time, and the disappearance time of lung wet rales, cough and sore throat in treatment group was significantly shorter than that in the control group, with significant difference between two groups (P<0.05). After treatment, the scores of cough, shortness of breath, body temperature and pulmonary rales in two groups was significantly decreased (P<0.05). And these scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the IL-6, IL-8 and TNF-α levels in two groups were significantly decreased (P<0.05). And the levels in the treatment group were significantly lower than those in the control group (P<0.01). Conclusion Jinye Baidu Granules combined with Reduning Injection can effectively alleviate clinical symptoms and signs of children with viral pneumonia, and reduce the occurrence of inflammatory reaction, which has a certain clinical application value.
[中图分类号]
[基金项目]