目的 探讨巴曲酶联合阿加曲班治疗下肢深静脉血栓的临床疗效。方法 选取2013年1月-2016年3月在天津市第五中心医院接受治疗的下肢深静脉血栓患者98例，随机分成对照组和治疗组，每组各49例。对照组患者静脉滴注阿加曲班注射液，前2 d，15 mg加入生理盐水100 mL，1次/d，第3天5 mg加入生理盐水150 mL，2次/d。治疗组在对照组的基础上静脉滴注巴曲酶注射液，20 U加入生理盐水100 mL，1次/d。两组患者均连续治疗7 d。评价治疗前后两组患者临床疗效、患肢深静脉通畅度和视觉痛觉评分（VAS）以及消肿率差异。结果 治疗后，对照组和治疗组总有效率分别为75.51%和97.96%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患肢深静脉通畅度评分显著升高，VAS评分显著降低，同组比较差异具有统计学意义（P<0.05）；且治疗组患者上述两项评分均明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患者消肿率明显高于对照组，两组比较差异具有统计学意义（P<0.05）。结论 巴曲酶联合阿加曲班治疗下肢深静脉血栓疾病疗效显著，具有一定的临床推广应用价值。

Objective To explore the clinical effect of batroxobin combined with argatroban in treatment of deep venous thrombosis of lower limb. Methods Patients (98 cases) with deep venous thrombosis of lower limb in the Fifth Central Hospital of Tianjin from January 2013 to March 2016 were randomly divided into control and treatment groups, and each group had 49 cases. Patients in the control group were iv administered with Argatroban Injection, the dosage for the first 2 d was that 15 mg added into normal saline 100 mL, once daily, and then 5 mg added into normal saline 150 mL from the third day, twice daily. Patients in the treatment group were iv administered with Batroxobin Injection on the basis of the control group, 20 U added into normal saline 100 mL, once daily. Patients in two groups were treated for 7 d. After treatment, clinical efficacy was evaluated, and limb deep vein patency scores, VAS scores, and the swelling rate in two groups before and after treatment was compared. Results After treatment, the clinical efficacy in the control and treatment groups were 75.51% and 97.96%, respectively, and there were differences between two groups (P<0.05). After treatment, the limb deep vein patency scores in two groups were significantly increased, VAS scores were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And these scores in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the swelling rate in the treatment group was significantly higher than that in the control group, with significant difference between two groups (P<0.05). Conclusion Batroxobin combined with argatroban has a significant effect in treatment of deep venous thrombosis of lower limb, which has a certain clinical application value.