目的 探究肾复康胶囊联合氢氯噻嗪片治疗慢性肾小球肾炎的临床疗效。方法 选取2015年9月-2016年9月渭南市中心医院肾内科收治的慢性肾小球肾炎患者91例，随机分成对照组（45例）和治疗组（46例）。对照组口服氢氯噻嗪片，2片/次，3次/d。治疗组在对照组基础上口服肾复康胶囊，5粒/次，3次/d。两组患者均治疗6周。观察两组的临床疗效，比较两组肾功能指标和24 h尿蛋白定量的情况。结果 治疗后，对照组和治疗组的总有效率分别为82.22%、97.83%，两组比较差异有统计学意义（P<0.05）。治疗后，两组肾小球滤过率均显著升高，而血清胱抑素C、尿素氮和血清肌酐水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗3、6周后，两组24 h尿蛋白定量均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组同期24 h尿蛋白定量明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 肾复康胶囊联合氢氯噻嗪片治疗慢性肾小球肾炎具有较好的临床疗效，能显著改善肾功能，降低24 h尿蛋白定量，安全性较好，具有一定的临床推广应用价值。

Objective To explore the clinical efficacy of Shenfukang Capsules combined with Hydrochlorothiazide Tablets in treatment of chronic glomerulonephritis. Methods Patients (91 cases) with chronic glomerulonephritis in Department of Endocrine of Weinan Central Hospital from September 2015 to September 2016 were randomly divided into the control group (45 cases) and the treatment group (46 cases). Patients in the control group were po administered with Hydrochlorothiazide Tablets, 2 tablets/time, three times daily. Patients in the treatment group were po administered with Shenfukang Capsules on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for 6 weeks. After treatment, the clinical efficacies were evaluated, and renal function and 24 h urinary protein content in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.22% and 97.83%, respectively, and there was difference between two groups (P<0.05). After treatment, the glomerular filtration rates in two groups were significantly increased, but the levels of serum cystatin C, urea nitrogen, and serum creatinine in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment for 3 and 6 weeks, 24 h urinary protein contents in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the 24 h urinary protein contents in the treatment group were significantly lower than that in the control group at the same time, with significant difference between two groups (P<0.05). Conclusion Shenfukang Capsules combined with Hydrochlorothiazide Tablets has clinical curative effect in treatment of chronic glomerulonephritis, can improve renal function, and decrease 24 h urinary protein contents, which has a certain clinical application value.