目的 探讨小儿豉翘清热颗粒联合炎琥宁注射液治疗小儿上呼吸道感染的临床疗效。方法 选取2016年1月-2017年1月在郑州大学附属洛阳中心医院接受治疗的小儿上呼吸道感染患者104例，根据治疗方案的差别分为对照组（52例）和治疗组（52例）。对照组患儿静脉滴注炎琥宁注射液，0.2~0.4 mL/kg，1次/d。治疗组在对照组的基础上口服小儿豉翘清热颗粒，1~3岁患儿2~3 g/次，4~6岁患儿3~4 g/次，7~10岁患儿4~6 g/次，3次/d。两组患儿治疗1周。评价两组患儿临床疗效，同时比较治疗前后两组患儿临床症状消失时间和血清学指标变化。结果 治疗后，对照组和治疗组总有效率分别为80.65%、98.08%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患儿的退热、止咳、咽喉红肿、腹泻及鼻塞流涕等消失时间均短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患儿血清超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和降钙素原（PCT）水平均显著降低，同组比较差异具有统计学意义（P<0.05）；且治疗组患儿降低水平明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 小儿豉翘清热颗粒联合炎琥宁注射液治疗小儿上呼吸道感染疗效显著，可有效改善临床症状及降低血清炎症因子水平，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Xiao'er Chiqiao Qingre Granules combined with Potassium Sodium Dehydroandrographolide Succinate Injection in treatment of children with upper respiratory tract infection. Methods Children (104 cases) with upper respiratory tract infection in Luoyang Central Hospital Affiliated to Zhengzhou University from January 2016 to January 2017 were divided into control (52 cases) and treatment (52 cases) groups based on different treatments. Children in the control group were iv administered with Potassium Sodium Dehydroandrographolide Succinate Injection, 0.2-0.4 mL/kg, once daily. Children in the treatment group were po administered with Xiao'er Chiqiao Qingre Granules on the basis of the control group, 2-3 g/time for 1-3 years children, 3-4 g/time for 4-6 years children, 4-6 g/time for 7-10 years children, three times daily. Children in two groups were treated for 1 week. After treatment, clinical efficacy was evaluated, and the disappearance time of clinical symptoms, serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 80.65% and 98.08%, respectively, and there were differences between two groups (P<0.05). After treatment, the disappearance time of fever, cough, swelling of the throat, diarrhea, and stuffy running nose in the treatment group was significantly shorter than that in the control group, with significant difference between two groups (P<0.05). After treatment, the hs-CRP, IL-6, TNF-α, and PCT levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the decreased degree in the treatment group was significantly better than that in the control group, with significant difference between two groups (P<0.05). Conclusion Xiao'er Chiqiao Qingre Granules combined with Potassium Sodium Dehydroandrographolide Succinate Injection has good clinical efficacy in treatment of children with upper respiratory tract infection, can effectively improve the clinical symptoms with decreasing serum inflammatory factors levels, which has a certain clinical application value.