目的 探讨冠心宁注射液联合酒石酸美托洛尔片治疗冠心病心绞痛的临床疗效。方法 选取2015年4月-2017年5月汝州市第一人民医院收治的冠心病心绞痛患者110例，随机分为对照组和治疗组，每组各55例。对照组口服酒石酸美托洛尔片，初始剂量12.5 mg/次，2周后增至25 mg/次，2次/d。治疗组在对照组基础上静脉滴注冠心宁注射液，20 mL加入到生理盐水或5%葡萄糖250 mL中，1次/d。两组患者均治疗2个月。观察两组的临床疗效，比较两组的血流动力学、血脂水平、生活质量评分。结果 治疗后，对照组和治疗组的心绞痛改善率分别为78.2%、92.7%，两组比较差异有统计学意义（P<0.05）。治疗后，对照组和治疗组的心电图改善率分别为72.7%、89.1%，两组比较差异有统计学意义（P<0.05）。治疗后，两组全血高切黏度、全血低切黏度、血浆黏度、纤维蛋白原均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组总胆固醇（TC）、三酰甘油（TG）和低密度脂蛋白胆固醇（LDL-C）水平均显著下降，而高密度脂蛋白胆固醇（HDL-C）水平显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组躯体活动受限程度、心绞痛稳定状态、心绞痛发作情况、治疗满意程度和疾病认知程度评分均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显高于对照组，两组比较差异具有统计学意义（P<0.05）。结论 冠心宁注射液联合酒石酸美托洛尔片治疗冠心病心绞痛具有较好的临床疗效，可调节血流动力学指标和血脂水平，提高患者生活质量，具有一定的临床推广应用价值。

Objective To investigate the effect of Guanxinning Injection combined with Metoprolol Tartrate Tablets in treatment of angina pectoris of coronary heart disease. Methods Patients (110 cases) with angina pectoris of coronary heart disease in Ruzhou First People's Hospital from April 2015 to May 2017 were randomly divided into control and treatment groups, and each group had 55 cases. Patients in the control group were po administered with Metoprolol Tartrate Tablets, starting dosage 12.5 mg/time, increased to 25 mg/time after treatment for 2 weeks, once daily. Patients in the treatment group were iv administered with Guanxinning Injection on the basis of the control group, 20 mL added into normal saline (or 5% glucose solution) 250 mL, once. Patients in two groups were treated for 2 months. After treatment, the clinical efficacies were evaluated, and hemodynamic, blood lipid level, quality of life score in two groups were compared. Results After treatment, the improvement rate of angina pectoris in the control and treatment groups were 78.2% and 92.7%, respectively, and there was difference between two groups (P<0.05). After treatment, the improvement rate of electrocardiogram in the control and treatment groups were 72.7% and 89.1%, respectively, and there was difference between two groups (P<0.05). After treatment, whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, and fibrinogen in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of TC, TC, and LDL-C in two groups were significantly decreased, but the levels of HDL-C in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the scores of physical activity restriction, angina pectoris stability, angina pectoris attack, treatment satisfaction, and angina pectoris awareness in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Guanxinning Injection combined with Metoprolol Tartrate Tablets has clinical curative effect in treatment of angina pectoris of coronary heart disease, can regulate hemodynamic indexes and blood lipid level, and increase quality of life, which has a certain clinical application value.