目的 对西安市中心医院质子泵抑制剂在儿科的应用情况进行分析，为规范和指导临床合理用药、加强儿童用药监护提供依据。方法 采用回顾性调查方法，利用医院PASS系统，统计2015年西安市中心医院质子泵抑制剂在住院患儿的使用情况，针对品种选择、适应症、给药剂量、溶媒选择及给药途径等分析合理性。结果 质子泵抑制剂在住院患儿中的使用人次及销售金额均以兰索拉唑粉针剂为首。观察的79份病例中，不合理用药现象主要包括选药品种不适宜、无适应症用药、用法用量及给药途径不适宜、重复用药等。结论 西安市中心医院质子泵抑制剂在患儿中的使用存在不合理现象，建议加强该类药物的规范化管理，以便在提高药效的同时降低患儿的用药风险。

Objective To analyze the clinical use of proton pump inhibitors (PPIs) in pediatric inpatients of Xi'an Central Hospital, to provide reference for the rational use of PPIs in pediatric and strengthening supervision on children. Methods The hospital PASS system was used for statistics on the use of PPIs in pediatric inpatients in Xi'an Central Hospital in 2015 by retrospective investigation, and the rationality of using PPIs in respect of indication, drug selection, drug dosage, solvent selection, and administration route were analyzed. Results The most use times and sales amount of PPIs was Lansoprazole Injection in pediatric inpatients. In the observed patients (79 cases), the irrational phenomenon mainly included inappropriate selection of drugs, non-indication, unsuitable usage, and inappropriate route of administration, and repeated medication and so on. Conclusion There is unreasonable use of PPIs in pediatric inpatients in Xi'an Central Hospital. Rational use of PPIs should be strengthened to improve the efficacy of the drug at the same time reduce the associated risk of adverse effects.