[关键词]
[摘要]
目的 观察阿法骨化醇软胶囊联合雷洛昔芬治疗绝经后骨质疏松症的临床疗效。方法 选取2015年1月—2016年1月南阳市骨科医院收治的绝经后妇女骨质疏松症患者102例,随机分为对照组和治疗组,每组各51例。对照组患者口服盐酸雷洛昔芬片,1片/次,1次/d。治疗组在对照组的基础上口服阿法骨化醇软胶囊,1粒/次,1次/d。两组患者均治疗6个月。评价治疗后两组患者临床疗效,同时比较治疗前后两组骨强度、骨代谢标记物含量和不良反应差异。结果 治疗后,对照组和治疗组临床总有效率分别为82.35%、96.08%,两组比较差异具有统计学意义(P< 0.05)。治疗后,两组患者骨密度和骨矿含量均明显升高(P< 0.05);且治疗后治疗组骨强度指标明显高于对照组(P< 0.05)。治疗后,两组患者I型胶原交联氨基端肽(NTX I)、I型胶原交联羧基端肽(CTX I)、抗酒石酸酸性磷酸酶5b(TRACP5b)和血骨钙素(BGP)含量均明显降低(P< 0.05);且治疗组患者的骨代谢标记物含量明显低于对照组(P< 0.05)。结论 阿法骨化醇软胶囊联合雷洛昔芬治疗绝经后骨质疏松症疗效较好,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To observe the clinical efficacy of Alfacalcidol Soft Capsules combined with raloxifene in treatment of postmenopausal osteoporosis. Methods Women (106 cases) with postmenopausal osteoporosis in Nanyang Orthopedic Hospital from January 2015 to January 2016 were randomly divided into control and treatment groups, and each group had 51 cases. Patients in the control group were po administered with Raloxifene Hydrochloride Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Alfacalcidol Soft Capsules on the basis of the control group, 1 grain/time, once daily. Patients in two groups were treated for 6 months. After treatment, clinical efficacy was evaluated, and bone intensity, bone metabolic markers, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 82.35% and 96.08%, respectively, and there were differences between two groups (P < 0.05). After treatment, the bone density and bone mineral content in two groups were significantly increased (P < 0.05). And the bone intensity indexes in the treatment group were significantly higher than those in the control group (P < 0.05). After treatment, the NTX I, CTX I, TRACP5b, and BGP in two groups were significantly decreased (P < 0.05). And the levels of bone metabolic markers in treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Alfacalcidol Soft Capsules combined with raloxifene has good effects in treatment of postmenopausal osteoporosis, which has a certain clinical application value.
[中图分类号]
[基金项目]