目的 探讨红花逍遥片联合炔雌醇环丙孕酮治疗多囊卵巢综合征患者的临床效果。方法 收集2014年8月—2016年8月在郑州人民医院就诊的多囊卵巢综合征患者144例，随机分为对照组和治疗组，每组各72例。对照组患者口服炔雌醇环丙孕酮片，1片/次，连服21 d，停用7 d后开始下一疗程。治疗组患者在对照组的基础上口服红花逍遥片，3片/次，3次/d。两组患者均连续治疗3个月。评价治疗后两组患者临床疗效，同时比较治疗前后两组血糖指标、性激素水平以及排卵和妊娠情况。结果 治疗后，对照组总有效率为72.22%，显著低于治疗组的91.67%，两组比较差异具有统计学意义（P< 0.05）。治疗后，两组患者空腹胰岛素（FINS）和胰岛素抵抗指数（HOMA-IR）较治疗前显著降低（P< 0.05）；且治疗组患者FINS和HOMA-IR较对照组患者更低（P< 0.05）。治疗后，两组患者血清睾酮（TSTO）、卵泡刺激素（FSH）、黄体生成素（LH）和LH/FSH较治疗前显著降低（P< 0.05）；且治疗组患者上述性激素水平降低程度明显优于对照组（P< 0.05）。治疗后随访3个月发现，对照组患者的排卵率和妊娠率分别为66.67%、47.22%，均分别显著低于治疗组的86.11%、68.06%，两组比较差异具有统计学意义（P< 0.05）。结论 红花逍遥片联合炔雌醇环丙孕酮治疗多囊卵巢综合征患者优势明显，能降低机体性激素水平，改善胰岛素抵抗、促进排卵、提高妊娠，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Honghua Xiaoyao Tablets combined with ethinylestradiol and cyproterone in treatment of polycystic ovary syndrome. Methods Patients (144 cases) with polycystic ovary syndrome in People's Hospital of Zhengzhou from August 2014 to August 2016 were randomly divided into control and treatment groups, and each group had 72 cases. Patients in the control group were po administered with Ethinylestradiol and Cyproterone Acetate Tablets, 1 tablet/time, and they were treated for 21 d, then the next course of treatment began after withdrawal for 7 d. Patients in the treatment group were po administered with Honghua Xiaoyao Tablets on the basis of control group, 3 tablets/time, three times daily. Patients in two groups were treated for 3 months. After treatment, clinical efficacy was evaluated, and the blood glucose indexes, sex hormones levels, ovulation, and pregnancy in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 72.22%, which was significantly lower than 91.67% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the FINS and HOMA-IR in two groups were significantly decreased (P < 0.05). And the FINS and HOMA-IR in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the TSTO, FSH, LH, and LH/FSH levels in two groups were significantly decreased (P < 0.05). And the sex hormones levels in treatment group were significantly better than those in the control group (P < 0.05). Three month's follow-up after treatment, ovulation and pregnancy rate in the control group were 66.67% and 47.22%, which were significantly lower than 86.11% and 68.06% in the treatment group, respectively, and there were differences between two groups (P < 0.05). Conclusion Honghua Xiaoyao Tablets combined with ethinylestradiol and cyproterone has obvious advantages in treatment of polycystic ovary syndrome, can reduce sex hormone level, improve insulin resistance,promote ovulation and improve the pregnancy, which has a certain clinical application value.