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[摘要]
目的 探讨槐杞黄颗粒联合氢化可的松治疗儿童过敏性紫癜的临床疗效。方法 收集2012年8月—2016年8月在扶风县中医医院接受治疗的儿童过敏性紫癜患儿60例,根据治疗方案的差别分为对照组(30例)和治疗组(30例)。对照组患儿静脉滴注注射用氢化可的松琥珀酸钠,5~10 mg/(kg·d),2次/d,症状消失后逐渐减量,2周后停药,并对症治疗。治疗组患儿在对照组的基础上口服槐杞黄颗粒,2~3岁半袋/次,3~12岁1袋/次,均为2次/d。两组患儿均治疗2周。评价治疗后两组患者临床疗效,同时比较两组患儿治疗前后临床症状和炎性因子水平。结果 治疗后,对照组和治疗组总有效率分别为73.33%和96.67%,两组比较差异具有统计学意义(P< 0.05)。治疗后,治疗组患儿皮疹消退时间、紫癜消退时间、关节疼痛改善时间和消化症状改善时间均显著短于对照组,两组比较差异具有统计学意义(P< 0.05)。治疗后,两组患儿IL-4、IL-13和肿瘤坏死因子-α(TNF-α)水平均明显低于同组治疗前,而γ-干扰素(IFN-γ)水平明显高于同组治疗前,同组比较差异具有统计学意义(P< 0.05);且治疗组患者上述炎性因子指标改善情况明显好于对照组,两组比较差异具有统计学意义(P< 0.05)。结论 槐杞黄颗粒联合氢化可的松治疗儿童过敏性紫癜的临床疗效显著,可明显改善患儿临床症状和血清细胞因子水平,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effects of Huaiqihuang Granules combined with hydrocortisone in treatment of children with allergic purpura. Methods Children (60 cases) with allergic purpura in Fufeng County Hospital of TCM from August 2012 to August 2016 were randomly divided into control (30 cases) and treatment (30 cases) groups. Children in the control group were iv administered with Hydrocortisone Sodium Succinate for injection, 5-10 mg/(kg·d), twice daily, the dosage was gradually decreased after symptoms disappeared, and withdrawal after 2 weeks, then took symptomatic treatment. Children in the treatment group were po administered with Huaiqihuang Granules on the basis of the control group, half bag/time for 2-3 years children, 1 bag/time for 3-12 years children, twice daily. Children in two groups were treated for 2 weeks. After treatment, clinical efficacy was evaluated, and the clinical symptom and the inflammatory factors levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 73.33% and 96.67%, respectively, and there were differences between two groups (P < 0.05). After treatment, the rash and purpura regression time, joint pain and digestive symptoms improvement time in the treatment group were significantly shorter than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the IL-4, IL-13 and TNF-α levels in two groups were significantly decreased, but IFN-γ levels were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the improvement of inflammatory factors levels in treatment group was significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Huaiqihuang Granules combined with hydrocortisone has significant effect in treatment of children with allergic purpura, can significantly improve the clinical symptoms and serum cytokine levels, which has a certain clinical application value.
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