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[摘要]
目的 观察辛芩颗粒联合糠酸莫米松鼻喷雾剂治疗儿童变应性鼻炎的临床疗效。方法 选取2015年3月—2016年12月在成都市妇女儿童中心医院就诊的变应性鼻炎患儿238例,随机分成对照组和治疗组,每组各119例。对照组患儿清晨鼻喷糠酸莫米松鼻喷剂,2喷/次,1次/d;治疗组患儿在对照组的基础上口服辛芩颗粒,5 g/次,2次/d。两组患儿均治疗30 d。评价治疗后两组患者临床疗效,同时比较治疗前后两组症状评分和体征评分以及IL-10和IgE水平改变。结果 治疗后,对照组和治疗组的总有效率分别为78.15%、90.76%,两组比较差异具有统计学意义(P< 0.05)。治疗后,两组患儿临床症状和体征评分均明显降低,同组比较差异具有统计学意义(P< 0.05);且治疗后治疗组患儿上述评分显著低于对照组,两组比较差异具有统计学意义(P< 0.05)。治疗后,两组患儿IL-10水平显著升高,IgE水平显著降低,同组比较差异具有统计学意义(P< 0.05);且治疗组患儿IL-10和IgE水平明显优于对照组,两组比较差异具有统计学意义(P< 0.05)。结论 辛芩颗粒联合糠酸莫米松鼻喷雾剂治疗儿童变应性鼻炎效果良好,能够有效的改善患儿的临床症状,且安全性较高,具有一定的临床推广应用价值。
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[Abstract]
Objective To observe the curative effect of Xinqin Granules combined with mometasone furoate in treatment of children with allergic rhinitis. Methods Children (238 cases) with allergic rhinitis in Chengdu Women and Children's Central Hospital from March 2015 to December 2016 were randomly divided into control and treatment groups, and each group had 119 cases. Children in the control group were nasal spray administered with Mometasone Furoate Aqueous Nasal Spray in the morning, 2 sprays/time, once daily. Children in the treatment group were po administered with Xinqin Granules on the basis of the control group, 5 g/time, twice daily. Children in two groups were treated for 30 d. After treatment, clinical efficacy was evaluated, and the changes of the symptom scores and sign scores, the IL-10, and IgE levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 78.15% and 90.76%, respectively, and there were differences between two groups (P < 0.05). After treatment, the clinical symptom and sign scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And these scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the IL-10 levels in two groups were significantly increased, IgE levels were significantly decreased, and there were differences in the same group (P < 0.05). And the IL-10 and IgE levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Xinqin Granules combined with mometasone furoate has good clinical effect in treatment of children with allergic rhinitis, can effectively relieve clinical symptoms with high security, which has a certain clinical application value.
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