目的 探究疏风解毒胶囊联合丹参川芎嗪注射液治疗慢性阻塞性肺疾病急性加重期（AECOPD）的临床疗效。方法 选取2015年1月—2016年6月在上海市浦东新区康桥社区卫生服务中心接受治疗的老年AECOPD患者98例为研究对象，随机分为对照组和治疗组，每组各49例。对照组患者静脉滴注丹参川芎嗪注射液，10 mL/次，1次/d。治疗组患者在对照组的基础上口服疏风解毒胶囊，10粒/次，3次/d。两组患者均持续治疗2周。评价治疗后两组患者临床疗效，同时比较治疗前后两组患者肺功能、血气功能、白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF-α）水平以及临床症状改善情况。结果 治疗后，对照组和治疗组的总有效率分别为79.6%、95.9%，两组比较差异具有统计学意义（P< 0.05）。治疗后，两组患者一秒用力呼气容积（FEV₁）、用力肺活量（FVC）和FEV₁/FVC指标均明显提高（P< 0.05）；且治疗组患者上述肺功能指标明显优于对照组（P< 0.05）。治疗后，两组患者二氧化碳分压（pCO₂）、IL-8和TNF-α水平均显著降低，氧分压（pO₂）、血氧饱和度（SaO₂）均明显升高，同组比较差异具有统计学意义（P< 0.05）；且治疗组上述指标改善情况明显优于对照组，两组比较差异具有统计学意义（P< 0.05）。治疗后，两组呼吸困难评分均明显降低，同组比较差异具有统计学意义（P< 0.05）；治疗后，治疗组患者呼吸困难评分明显低于对照组，且咳痰、咳嗽、喘息、胸闷等临床症状的改善例数明显多于对照组，两组比较差异具有统计学意义（P< 0.05）。结论 疏风解毒胶囊联合丹参川芎嗪注射液能够明显提高AECOPD患者的肺功能、血气功能并改善临床症状，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Shufeng Jiedu Capsules combined with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Patients (98 cases) with AECOPD in Kangqiao Community Health Service Center of Pudong New District in Shanghai from January 2015 to June 2016 were randomly divided into control and treatment groups, and each group had 49 cases. Patients in the control group were iv administered with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection, 10 mL/time, once daily. Patients in the treatment group were po administered with Shufeng Jiedu Capsules on the basis of the control group, 10 grains/time, three times daily. Patients in two groups were treated for two weeks. After treatment, clinical efficacy was evaluated, and lung function, blood gas function, IL-8 and TNF-α levels, and the improvement of clinical symptoms in two groups before and after treatment were compared.Results After treatment, the clinical efficacy in the control and treatment groups were 79.6% and 95.9%, respectively, and there were differences between two groups (P < 0.05). After treatment, the FEV₁, FVC and FEV₁/FVC indexes in two groups were significantly increased(P < 0.05). And the lung function indexes in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the pCO₂, IL-8 and TNF-α levels in two groups were significantly decreased, pO₂ and SaO₂ were significantly increased, and there were differences in the same group (P < 0.05). And the improvement of these indicators in the treatment group was significantly better than that in the control group, with significant difference between two groups (P < 0.05). After treatment, the dyspnea scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the dyspnea scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the patients of improved clinical symptoms of expectoration, coughing, wheezing, chest tightness in the treatment group was significantly more than patients in the control group, with significant difference between two groups (P < 0.05). Conclusion Shufeng Jiedu Capsules combined with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection can significantly improve lung function, blood gas function, and clinical symptoms of AECOPD patients, which has a certain clinical application value.

上海市浦东新区卫生系统优秀社区适宜人才培养项目（PWRs2014-07）