目的 探索芪苈强心胶囊联合坎地沙坦酯治疗慢性肺心病急性加重期的治疗疗效。方法 选取2016年1月—2016年12月于北京市隆福医院接受治疗的慢性肺心病急性加重期患者86例，随机分成对照组和治疗组，每组各43例。对照组口服坎地沙坦酯片，4 mg/次，1次/d。治疗组在对照组治疗基础上口服芪苈强心胶囊，4粒/次，3次/d。两组患者均连续治疗2周。观察两组的临床疗效，同时比较两组治疗前后氧分压、二氧化碳分压、血氧饱和度的变化情况。随访120 d，评价两组患者的生活质量评分。结果 治疗后，对照组和治疗组的总有效率分别为79.07%、90.70%，两组比较差异具有统计学意义（P< 0.05）。治疗后，两组患者氧分压、血氧饱和度均显著升高，同组治疗前后差异有统计学意义（P< 0.05）；治疗后，治疗组氧分压、血氧饱和度均显著高于对照组，两组比较差异具有统计学意义（P< 0.05）。随访后，两组生活质量评分均显著升高，同组治疗前后差异有统计学意义（P< 0.05）；随访后，治疗组生活质量评分高于对照组，两组比较差异具有统计学意义（P< 0.05）。结论 芪苈强心胶囊联合坎地沙坦酯治疗慢性肺心病急性加重期有显著效果，可显著改善血气分析指标和生活质量评分，具有一定的临床推广应用价值。

Objective To explore the effect of Qili Qiangxin Capsules combined with candesartan cilexetil in treatment of acute exacerbation of chronic pulmonary heart disease. Methods Patients (86 cases) with acute exacerbation of chronic pulmonary heart disease in Beijing Longfu Hospital from January 2016 to December 2016 were randomly divided into control (43 cases) and treatment (43 cases) groups. Patients in the control group were po administered with Candesartan Cilexetil Tablets, 4 mg/time, once daily. Patients in the treatment group were po administered with Qili Qiangxin Capsules, 4 grains/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the changes of pO₂, pCO₂and SaO₂ in two groups before and after treatment were compared. Follow-up for 120 d, life quality scores in two groups were evaluated. Results After treatment, the clinical efficacy in the control and treatment groups were 79.07% and 90.70%, respectively, and there was difference between two groups (P < 0.05). After treatment, pO₂ and SaO₂ in two groups increased statistically, but pCO₂ in two groups decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, pO₂ and SaO₂ in the treatment group were higher than those in the control group, and pCO₂ in the treatment group was lower than that in the control group, and there was difference between two groups (P < 0.05). After follow-up, life quality scores in two groups increased statistically, and the difference was statistically significant in the same group (P < 0.05). After follow-up, life quality score in the treatment group was higher than that in the control group, and there was difference between two groups (P < 0.05). Conclusion Qili Qiangxin Capsules combined with candesartan cilexetil has a significant effect in treatment of acute exacerbation of chronic pulmonary heart disease, and can significantly improve blood gas analysis indexes and life quality score, which has a certain clinical application value.