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[摘要]
在脑缺血再灌注损伤的病理过程中,现有的文献数据表明氧自由基在其中发挥重要作用,而其来源有多种途径。在许多细胞中,NADPH氧化酶是过氧化物产生的一个主要因素,与氧自由基的病理作用关系密切。NADPH氧化酶2(NOX2)是NADPH氧化酶的一个亚型,近年研究表明,其过度表达与脑缺血再灌注损伤的发生发展关系密切。主要对NOX2在脑缺血再灌注损伤中的作用机制进行综述。
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[Abstract]
Oxygen free radicals generated from different ways play a significant role in the pathogenesis of cerebral ischemia reperfusion injury (CIRI) according to available literatures. As a key factor in the production of peroxides in many cells, NADPH oxidase is closely related to the pathogenesis of oxygen free radicals. Recent studies have shown that the expression of NADPH oxidase 2 (NOX2), a subtype of NADPH oxidase, which plays an important role in the development of CIRI. The mechanism of NOX2 in CIRI is reviewed in this paper.
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