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[摘要]
目的 探讨大蒜素胶囊联合康复新液治疗复发性口腔溃疡的临床疗效。方法 选取2015年1月—2016年1月上海市嘉定区牙病防治所收治的复发性口腔溃疡患者104例,采用随机数字表法均分为对照组和治疗组,每组各52例。对照组清水漱口后含漱康复新液,10 mL/次,30 min内不进食和漱口,3次/d。治疗组在对照组基础上口服大蒜素胶囊,2粒/次,3次/d。两组均治疗3个月。观察两组的临床疗效,比较两组的T淋巴细胞亚群、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和视觉模拟量表(VAS)评分。结果 治疗后,对照组和治疗组的总有效率分别为76.92%、92.31%,两组比较差异有统计学意义(P< 0.05)。治疗后,两组CD3+、CD4+和CD4+/CD8+水平均显著升高,而CD8+水平均显著下降,同组治疗前后比较差异有统计学意义(P< 0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P< 0.05)。治疗后,两组唾液TNF-α和IL-6水平均显著降低,同组治疗前后比较差异有统计学意义(P< 0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P< 0.05)。治疗后,两组VAS评分均显著降低,同组治疗前后比较差异有统计学意义(P< 0.05);且治疗组VAS评分的下降程度明显优于对照组,两组比较差异具有统计学意义(P< 0.05)。结论 大蒜素胶囊联合康复新液治疗复发性口腔溃疡具有较好的临床疗效,可改善临床症状,提高机体免疫功能,降低炎性反应,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effect of Garlicin Capsules combined with Kangfuxin Liquid in treatment of recurrent oral ulcer. Methods Patients (104 cases) with recurrent oral ulcer in Jading District Dental Prevention and Treatment Clinic of Shanghai from January 2015 to January 2016 were randomly divided into control and treatment groups according to random number table method, and each group had 52 cases. Patients in the control group were gargling administered with Kangfuxin Liquid after gargling with water, without eating or gargling within 30 min, 10 mL/time, three times daily. Patients in the treatment group were po administered with Garlicin Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and T lymphocyte subsets, TNF-α, IL-6, and VAS scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.92% and 92.31%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of CD3+, CD4+, and CD4+/CD8+ in two groups were significantly increased, but the levels of CD8+ in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of TNF-α and IL-6 in saliva in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the VAS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the VAS score in the treatment group was significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Garlicin Capsules combined with Kangfuxin Liquid has clinical curative effect in treatment of recurrent oral ulcer, can improve clinical symptoms, enhance immune function, and decrease inflammatory reaction, which has a certain clinical application value.
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