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[摘要]
目的 探讨黄藤素分散片联合替硝唑治疗慢性盆腔炎的临床疗效。方法 选取2015年10月—2016年10月三门峡市中心医院进行治疗的慢性盆腔炎患者92例,根据治疗方案分为对照组(46例)和治疗组(46例)。对照组静脉滴注替硝唑氯化钠注射液,1支/次,2次/d。治疗组在对照组的基础上口服黄藤素分散片,4片/次,3次/d。两组均连续治疗2周。治疗后,观察两组患者临床疗效,同时比较治疗前后两组患者临床症状评分、血清细胞因子水平及不良反应情况。结果 治疗后,对照组和治疗组的总有效率分别为80.43%、97.82%,两组比较差异具有统计学意义(P< 0.05)。治疗后,两组血清肿瘤坏死因子-α(TNF-α)、单核细胞趋化蛋白-1(MCP-1)和可溶性细胞黏附因子-1(sICAM-1)水平均较治疗前明显降低,IL-4水平明显增高,同组比较差异有统计学意义(P< 0.05);且治疗组上述血清细胞因子水平显著优于对照组,两组比较差异具有统计学意义(P< 0.05)。治疗后,两组患者临床症状评分均较治疗前明显降低,同组比较差异具有统计学意义(P< 0.05);且治疗组临床症状评分低于对照组,两组比较差异具有统计学意义(P< 0.05)。两组均无明显不良反应发生。结论 黄藤素分散片联合替硝唑治疗慢性盆腔炎效果显著,可明显改善患者临床症状和细胞因子水平,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effect of Huangtengsu Dispersible Tablets combined with tinidazole in treatment of chronic pelvic inflammation. Methods Patients (92 cases) with chronic pelvic inflammation in Sanmenxia Central Hospital from October 2015 to October 2016 were randomly divided into control (46 cases) and treatment groups (46 cases), based on different treatments. Patients in the control group were iv administered with Tinidazole and Sodium Chloride Injection, one tube/time, twice daily. Patients in the treatment group were po administered with Huangtengsu Dispersible Tablets on the basis of control group, 4 tablets/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and clinical symptoms scores, serum cytokine levels, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.43% and 97.82%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of TNF-α, MCP-1, and sICAM-1 in serum were significantly decreased, but IL-4 level was significantly increased, and the difference was statistically significant in the same group (P < 0.05). And those indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, clinical symptoms scores in two groups were significantly decreased, the difference was statistically significant in the same group (P < 0.05). And the clinical symptoms scores in the treatment group was significantly lower than that in the control group, with significant difference between two groups (P < 0.05). There were no adverse reactions in two groups. Conclusion Huangtengsu Dispersible Tablets combined with tinidazole has a significant curative effect in treatment of chronic pelvic inflammation, can significantly improve the clinical symptoms and cytokines levels, which has a certain clinical application value.
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