目的 讨论喜炎平注射液联合注射用磷酸肌酸钠治疗小儿病毒性心肌炎的疗效及其安全性。方法 选取天津市泰达医院2014年6月—2016年6月收治的病毒性心肌炎患儿78例，随机分为对照组（36例）和治疗组（42例）。对照组静脉滴注注射用磷酸肌酸钠，1 g溶于5%葡萄糖注射液100 mL中后30～45 min给药，1次/d。治疗组在对照组基础上静脉滴注喜炎平注射液，5～10 mg/kg（0.2～0.4 mL/kg）加入5%葡萄糖注射液或0.9%氯化钠注射液100～250 mL中，1次/d。两组患儿均连续给药14 d。观察两组的临床疗效，比较治疗前后两组心肌学指标和心肌钙蛋白（cTnI）改善情况。结果 治疗后，对照组、治疗组总有效率分别为83.3%、96.6%，两组总有效率比较差异具有统计学意义（P< 0.05）。治疗后，两组血清磷酸肌酸激酶（CK）、磷酸肌酸激酶同工酶（CK-MB）、天冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH）、心肌钙蛋白（cTnI）水平均显著降低，同组治疗前后比较差异具有统计学意义（P< 0.05）；且治疗组各指标明显低于对照组，两组比较差异具有统计学意义（P< 0.05）。治疗过程中治疗组和对照组患者均未出现明显的不良反应。结论 喜炎平注射液联合磷酸肌酸钠注射液治疗小儿病毒性心肌炎具有较好的临床疗效，能够明显改善心肌学指标和心肌钙蛋白，具有一定的临床推广应用价值。

Objective To discuss the curative effect of Xiyanping Injection combined with Creatine Phosphate Sodium for injection in treatment of viral myocarditis in children and its safety. Methods Children (78cases) with viral myocarditis in Tianjin TEDA Hospital from June 2014 to June 2016 were randomly divided into control group (36 cases) and treatment group (42 cases). Children in the control group in the control group were iv administered with Creatine Phosphate Sodium for injection, 1 g added into 5% Glucose Solution 100 mL, then administered before 30-45 min, once daily. Patients in the treatment group were iv administered with Xiyanping Injection, 5-10 mg/kg (0.2-0.4 mL/kg) added into 5% Glucose Solution or normal saline 100-250 mL, once daily. Children in two groups were treated for 14 d. After treatment, the efficacy was evaluated, and myocardial markers and cardiac troponin (cTnI) were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 83.3% and 96.6%, respectively, and there was difference between two groups (P < 0.05). After treatment, serum CK, CK-MB AST, LDH and cTnI levels in two groups were significantly decreased, and the differences were statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). There were no obvious adverse reactions in two groups. Conclusion Xiyanping Injection combined with Creatine Phosphate Sodium for injection has clinical curative effect in the treatment of viral myocarditis, can improve myocardial marker and cTnI, and have no obvious adverse reactions, which has a certain clinical application value.