目的 探讨心脉隆注射液联合地高辛治疗慢性充血性心力衰竭的临床疗效。方法 选取2016年2月—2017年2月在中国人民解放军第四五四医院进行治疗的慢性充血性心力衰竭患者88例，随机分成对照组（44例）和治疗组（44例）。对照组口服地高辛片，0.25 mg/次，1次/d。治疗组在对照组的基础上静脉滴注心脉隆注射液，4 mL加入生理盐水100 mL中，2次/d。两组均连续治疗2周。比较两组患者治疗前后临床疗效、纽约心脏病协会（NYHA）分级、心功能和血清学指标变化。结果 治疗后，对照组总有效率为79.55%，显著低于治疗组的95.45%，两组比较差异具有统计学意义（P< 0.05）。治疗后，对照组NYHA分级的Ⅰ级例数显著低于治疗组，且Ⅳ级患者显著高于治疗组，两组患者NYHA分级比较差异具有统计学意义（P< 0.05）。治疗后，两组左心室舒张末期内径（LVEDD）、左心室收缩末期容积（LVESV）和左心室收缩末期内径（LVESD）水平显著降低，左心室射血分数（LVEE）和心指数（CI）指标明显升高，同组治疗前后比较差异具有统计学意义（P< 0.05）；且治疗组患者心功能指标显著优于对照组，两组比较差异具有统计学意义（P< 0.05）。两组血清N末端心房利钠肽（NT-proBNP）和白细胞介素-6（IL-6）水平均显著降低，血管内皮生长因子（VEGF）显著升高，同组治疗前后比较差异具有统计学意义（P< 0.05）；且治疗组患者血清学指标改善更显著，两组比较差异具有统计学意义（P< 0.05）。结论 心脉隆注射液联合地高辛治疗慢性充血性心力衰竭可明显改善患者心功能，降低机体炎症反应，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Xinmailong Injection combined with digoxin in treatment of chronic congestive heart failure. Methods Patients (88 cases) with chronic congestive heart failure in the NO. 454 Hospital of PLA from February 2016 to February 2017 were randomly divided into control (44 cases) and treatment (44 cases) groups. Patients in the control group were po administered with Digaoxin Tablets, 0.25 mg/time, once daily. Patients in the treatment group were iv administered with Xinmailong Injection on the basis of the control group, 4 mL added into normal saline 100 mL, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy, NYHA grade, cardiac function, and serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 79.55%, which were significantly lower than 95.45% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the Ⅰ grade of NYHA in the control group was significantly lower than that in the treatment group, and Ⅳ grade in the control group was significantly higher than that in the treatment group, with significant difference between two groups (P < 0.05). After treatment, the LVEDD, LVESV, and LVESD levels in two groups significantly decreased, but CI and LVEE levels significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the cardiac function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the NT-proBNP, ICAM-1, and IL-6 levels in two groups were significantly decreased, but VEGF level significantly increased, and there were differences in the same group (P < 0.05). And the improvement degree of the serological indexes in treatment group was more significantly than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Xinmailong Injection combined with digoxin has curative effect in treatment of chronic congestive heart failure can improve heart function and reduce the inflammation, which has a certain clinical application value.