目的 探讨氟比洛芬酯联合舒芬太尼用于老年膝关节置换术后镇痛作用的临床疗效。方法 选取2013年5月-2015年8月在河南省洛阳正骨医院接受膝关节置换术患者150例，根据其术中麻醉方式不同分为对照组（85例）和治疗组（65例）。对照组静脉滴注枸橼酸舒芬太尼注射液，0.04 μg/（kg·h）加入生理盐水至100 mL。治疗组静脉滴注枸橼酸舒芬太尼注射液和氟比洛芬酯注射液，枸橼酸舒芬太尼注射液0.02 μg/（kg·h）与氟比洛芬酯注射液1.0 mg/kg加入生理盐水至100 mL。观察两组的围手术期血流动力学、视觉模拟评分（VAS评分）、镇静评分（Ramsay评分）清醒时间和气管插管拔管时间。结果 手术开始和手术后2 h，治疗组收缩压（SBP）、舒张压（DBP）和平均动脉压（MAP）水平明显高于对照组，两组比较差异有统计学意义（P<0.05）。术后4、12、24 h，治疗组VAS评分低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组清醒时间和气管插管拔管时间均长于对照组，两组比较差异有统计学意义（P<0.05）。结论 氟比洛芬酯联合舒芬太尼用于老年膝关节置换术后疼痛作用具有较好的临床疗效，能改围手术期善血流动力学，缓解疼痛，延长清醒时间和气管插管拔管时间，具有一定的临床推广应用价值。

Objective To explore the clinical effect of flurbiprofen axetil combined with sufentanil in treatment of postoperative analgesia in elderly patients undergoing knee arthroplasty. Methods Elderly patients (150 cases) undergoing knee arthroplasty in Luoyang Bonesetting Hospital from May 2013 to August 2015 were enrolled in this study. According to the anesthesia method, patients were randomly divided into the control group (85 cases) and the treatment group (65 cases). Patients in the control group were iv administered with Sufentanil Citrate Injection, 0.04 μg/(kg·h) added into 100 mL normal saline. Patients in the treatment group were iv administered with Sufentanil Citrate Injection and Flurbiprofen Axetil Injection, and Sufentanil Citrate Injection 0.02μg/(kg·h) and Flurbiprofen Axetil Injection 1.0 mg/kg were added into normal saline to 100 mL. After treatment, perioperative hemodynamics, VAS scores, Ramsay scores, awake time and tracheal extubation time in two groups were compared. Results At the beginning of surgery and 2 h after surgery, SBP, DBP, and MAP in the treatment group were significantly higher than those in the control group, and there was difference between two groups (P < 0.05). At 4, 8 and 8 h after surgery, the VAS scores in the treatment group were lower than that in the control group, and there was difference between two groups (P < 0.05). After treatment, awake time and tracheal extubation time in the treatment group were longer than those in the control group, and there was difference between two groups (P < 0.05). Conclusion Flurbiprofen axetil combined with sufentanil has clinical curative effect in treatment of postoperative analgesia in elderly patients undergoing knee arthroplasty, and can improve perioperative hemodynamics, relieve pain, and prolong awake time and tracheal extubation time, which has a certain clinical application value.