目的 探讨香菇多糖注射液联合伊立替康治疗晚期结直肠癌的临床疗效。方法 选取2015年9月-2016年9月在南方医科大学南方医院接受治疗的晚期结直肠癌患者74例，随机分为对照组（37例）和治疗组（37例）。对照组静脉滴注盐酸伊立替康注射液，180 mg/m²加入250 mL生理盐水中，1次/3周。治疗组在对照组的基础上静脉滴注香菇多糖注射液，2 mL加入5%葡萄糖溶液250 mL中，1次/d。两组患者均连续治疗6周。治疗后，比较两组患者临床效果、生存质量改善情况和血清学指标。结果 治疗后，对照组与治疗组的客观缓解率（ORR）分别为48.65%、70.27%，临床获益率（CBR）分别为70.27%、91.89%，两组比较差异有统计学意义（P<0.05）。治疗后，对照组生存质量总改善率为72.97%，显著低于治疗组的94.59%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者基质金属蛋白酶-2（MMP-2）水平均下降，而白细胞介素-2（IL-2）和干扰素-γ（IFN-γ）水平均升高，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组患者的上述观察指标改善情况显著优于对照组患者，两组比较差异具有统计学意义（P<0.05）。结论 香菇多糖注射液联合伊立替康治疗晚期结直肠癌具有较好的临床疗效，可明显提高机体免疫能力和改善生活质量，具有一定的临床推广应用价值。

Objective To explore the clinical efficacy of Xianggu Duotang Injection combined with irinotecan in treatment of advanced colorectal cancer. Methods Patients (74 cases) with advanced colorectal cancer in Nanfang Hospital of Southern Medical University from September 2015 to September 2016 were randomly divided into control (37 cases) and treatment (37 cases) groups. Patients in the control group were iv administered with Irinotecan Hydrochloride Injection, 180 mg/m² diluted into 250 mL normal saline, once every 3 weeks. Patients in the treatment group were iv administered with Xianggu Duotang Injection on the basis of the control group, 2 mL added into 5% glucose solution (250 mL), once daily. Patients in two groups were treated for 6 weeks. After treatment, the clinical efficacy, improvement of quality of life, and serological indexes in two groups were compared. Results After treatment, ORR in the control and treatment groups were 48.65% and 70.27% respectively, and CBR in two groups were 70.27% and 91.89%, there was difference between two groups (P < 0.05). After treatment, the improvement rate of quality of life in the control group was 72.97%, which was significantly lower than 94.59% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, MMP-2 in two groups was significantly decreased, but IL-2 and IFN-γ were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observation indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Xianggu Duotang Injection combined with irinotecan has good clinical efficacy in treatment of advanced colorectal cancer, can significantly improve the immune capacity and quality of life, which has a certain clinical application value.