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目的 探讨肾衰宁颗粒联合沙格列汀片治疗糖尿病肾病的的临床疗效。方法 选取2015年9月-2016年8月云南省第二人民医院收治的糖尿病肾病患者70例,按照随机数字表法分为对照组和治疗组,每组各35例。对照组口服沙格列汀片,5 mg/次,1次/d。治疗组在对照组基础上口服肾衰宁颗粒,5 g/次,3次/d。两组均连续治疗8周。观察两组的临床疗效,比较两组血糖、肾功能和炎症因子的情况。结果 治疗后,对照组和治疗组的总有效率分别为65.71%、88.57%,两组比较差异有统计学意义(P<0.05)。治疗后,两组空腹血糖(FBG)、糖化血红蛋白(HbA1c)、血尿素氮(BUN)、尿白蛋白排泄率(UAER)和血清胱抑素C(Cys-C)均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组BUN、UAER和Cys-C的下降程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-18(IL-18)均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的下降程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 肾衰宁颗粒联合沙格列汀片治疗糖尿病肾病具有较好的临床疗效,能显著改善患者肾功能,降低血糖,减轻炎症反应,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effect of Shenshuaining Granules combined with Saxagliptin Tablets in treatment of diabetic nephropathy. Methods Patients (70 cases) with diabetic nephropathy in Yunnan Second People's Hospital from September 2015 to August 2016 were randomly divided into control and treatment groups, and each group had 35 cases. Patients in the control group were po administered with Saxagliptin Tablets, 5 mg/time, once daily. Patients in the treatment group were po administered with Shenshuaining Granules on the basis of the control group, 5 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and blood glucose, renal function, and inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 65.71% and 88.57%, respectively, and there was difference between two groups (P < 0.05). After treatment, FBG, HbA1c, BUN, UAER, and Cys-C in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). BUN, UAER, and Cys-C in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, TNF-α, IL-6, and IL-18 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). The observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Shenshuaining Granules combined with Saxagliptin Tablets has clinical curative effect in treatment of diabetic nephropathy, can significantly improve renal function, decrease blood glucose, and relieve inflammatory reaction, which has a certain clinical application value.
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