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目的 探讨双橘颗粒联合亮丙瑞林治疗子宫肌瘤的临床疗效。方法 选取2016年2月-2016年11月在宜昌市妇幼保健院接受治疗的子宫肌瘤患者84例,根据治疗方案的差别分为对照组(42例)和治疗组(42例)。对照组患者于月经周期的1~5 d开始皮下注射注射用醋酸亮丙瑞林微球,3.75 mg/次,1次/4周。治疗组患者在对照组的基础上口服双橘颗粒,10 g/次,3次/d。两组患者均治疗12周。观察两组患者临床疗效,同时比较治疗前后两组子宫肌瘤体积、血清细胞因子水平和性激素水平变化。结果 治疗后,对照组和治疗组的总有效率分别为71.43%、88.10%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者子宫肌瘤体积均比治疗前显著缩小(P<0.05);且治疗组患者子宫肌瘤体积缩小更显著(P<0.05)。治疗后,两组患者血清基质金属蛋白酶-9(MMP-9)、胰岛素样生长因子-1(IGF-I)和表皮细胞生长因子(EGF)水平均显著降低(P<0.05);且治疗组患者的血清细胞因子水平显著优于治疗后对照组(P<0.05)。治疗后,两组患者雌二醇(E2)、孕酮(P)、卵泡生成激素(FSH)及黄体生成激素(LH)水平均较同组治疗前明显降低(P<0.05);且治疗组患者性激素水平改善程度明显优于对照组(P<0.05)。结论 双橘颗粒联合亮丙瑞林治疗子宫肌瘤临床疗效显著,有利于瘤体缩小和血清性激素和细胞因子水平的改善,具有一定的临床推广应用价值。
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[Abstract]
Objective To evaluate the clinical efficacy of Shuangju Granules combined with leuprorelin in treatment of uterine myoma. Methods Patients (84 cases) with uterine myoma in Yichang Maternal and Child Health Care Hospital from February 2016 to November 2016 were divided into control (42 cases) and treatment (42 cases) groups based on different treatments. Patients in the control group were sc injected with Leuprorelin Acetate Microspheres for injection on day 1 - 5 of the menstrual cycle, 3.75 mg/time, once every 4 weeks. Patients in the treatment group were po administered with Shuangju Granules on the basis of the control group, 10 g/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacy was evaluated, and the changes of uterine fibroids volume, serum cytokine, and sex hormone levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 71.43% and 88.10%, respectively, and there was difference between two groups (P < 0.05). After treatment, the uterine fibroids volume in two groups was significantly reduced (P < 0.05). And the uterine fibroids volume in the treatment group was significantly smaller than that in the control group (P < 0.05). After treatment, the MMP-9, IGF-I and EGF levels in two groups were significantly decreased (P < 0.05). And the serum cytokine levels in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the E2, P, FSH and LH levels in two groups was significantly decreased (P < 0.05). And the improvement degree of the sex hormone levels in treatment group was significantly better than that in the control group (P < 0.05). Conclusion Shuangju Granules combined with leuprorelin has good clinical curative effect in treatment of uterine myoma, can significantly reduce the tumor volume and improve sex hormone and serum cytokine levels, which has a certain clinical application value.
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