目的 探讨帕罗西汀联合坦度螺酮治疗高血压致焦虑的临床疗效。方法 选取2016年1月-2017年1月在中国人民武装警察部队山东省总队医院进行治疗的104例高血压致焦虑患者，根据治疗方案分为对照组和治疗组，每组各52例。对照组口服枸橼酸坦度螺酮片，10 mg/次，3次/d。治疗组在对照组基础上口服盐酸帕罗西汀片，初始剂量20 mg/d，每周以10 mg递增，最大剂量不超过40 mg/d。两组患者均治疗4周。观察两组患者的临床疗效，同时比较两组治疗前后汉密尔顿焦虑量表（HAMA）评分、PHQ-9评分、WHOQOL-BREF评分、5-羟色胺（5-HT）、去甲肾上腺素（NA）及神经肽Y（NPY）水平的变化情况。结果 治疗后，对照组和治疗组的总有效率分别为80.77%、98.08%，两组比较差异有统计学意义（P<0.05）。治疗后，两组HAMA评分、PHQ-9评分、NPY、5-HT、NA均显著降低，而WHOQOL-BREF评分均显著增加，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组HAMA评分、PHQ-9评分、NPY、5-HT、NA低于对照组，WHOQOL-BREF评分高于对照组，两组比较差异具有统计学意义（P<0.05）。结论 帕罗西汀联合坦度螺酮治疗高血压致焦虑具有较好的临床疗效，可有效改善的焦虑症状，降低血清NPY、5-HT、NE水平，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of paroxetine combined with tandospirone in treatment of anxiety induced by hypertension. Methods Patients (104 cases) with anxiety induced by hypertension in General Team Hospital in Shandong Province of the Chinese People's Armed Police Force from January 2016 to January 2017 were divided into control and treatment groups according to the treatment, and each group had 52 cases. Patients in the control group were po administered with Tandospirone Citrate Tablets, 10 mg/time, three times daily. Patients in the treatment group were po administered with Paroxetine Hydrochloride Tablets on the basis of the control group, the initial dosage was 20 mg/d, and the maximum dosage did not exceed 40 mg/d by increasing 10 mg per week. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the changes of HAMA score, PHQ-9 score, WHOQOL-BREF score, 5-HT, NA, and NPY in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.77% and 98.08%, respectively, and there was difference between two groups (P < 0.05). After treatment, HAMA score, PHQ-9 score, NPY, 5-HT, and NA in two groups were significantly decreased, but WHOQOL-BREF score was significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, HAMA score, PHQ-9 score, NPY, 5-HT, and NA in the treatment group were lower than those in the control group, WHOQOL-BREF score was higher than that in the control group, and there were differences between two groups (P < 0.05). Conclusion Paroxetine combined with tandospirone has significant clinical efficacy in treatment of anxiety induced by hypertension, and can improve the anxiety symptoms effectively and reduce the levels of NPY, 5-HT, and NE, which has a certain clinical application value.