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[摘要]
目的 探讨心脉隆注射液联合多巴胺治疗慢性心力衰竭的临床疗效。方法 选取2015年1月-2016年2月濮阳市油田总医院收治的慢性心力衰竭患者66例,随机分为对照组和治疗组,每组各33例。对照组静脉滴注盐酸多巴胺注射液,30 mg/次,1次/d。治疗组在对照组的治疗基础上静脉滴注心脉隆注射液,5~10 mg/kg加入生理盐水250 mL,2次/d。两组均连续治疗14 d。观察两组的临床疗效,比较两组治疗前后爬楼梯阶数、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)和左室射血分数(LVEF)的变化情况。结果 治疗后,对照组和治疗组的总有效率分别为75.76%、93.94%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者爬楼梯阶数、LVEF显著升高,LVEDD、LVESD显著降低,同组治疗前后差异有统计学意义(P<0.05);治疗后,治疗组爬楼梯阶数、LVEF高于对照组,LVEDD、LVESD低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 心脉隆注射液联合多巴胺治疗慢性心力衰竭具有较好的临床疗效,可显著改善患者的运动耐力和心功能相关指标,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the curative effect of Xinmailong Injection combined with dopamine in treatment of chronic heart failure. Methods Patients (66 cases) with chronic heart failure in Puyang Oilfield General Hospital from January 2015 to February 2016 were randomly divided into control and treatment groups, and each group had 33 cases. Patients in the control group were iv administered with Dopamine Hydrochloride Injection, 30 mg/time, once daily. Patients in the treatment group were iv administered with Xinmailong Injection, 5 - 10 mg/kg added into 250 mL normal saline, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the changes of climb the stairs orders, LVEDD, LVESD, and LVEF in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 75.76% and 93.94%, respectively, and there was difference between two groups (P < 0.05). After treatment, the number of climbing stairs and LVEF in two groups were significantly increased, but LVEDD and LVESD were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the number of climbing stairs and LVEF in the treatment group were more than those in the control group, while LVEDD and LVESD in the treatment group were less than those in the control group, and there were differences between two groups (P < 0.05). Conclusion Xinmailong Injection combined with dopamine has significant clinical efficacy in treatment of chronic heart failure, and can significantly improve the exercise endurance and heart function correlation indexes, which has a certain clinical application value.
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