阿霉素是多种血液恶性肿瘤和实体瘤的主要治疗药物。然而，其临床应用受剂量相关性心脏毒性的限制。阿霉素诱导心脏毒性的机制可能涉及多种信号通路，包括自由基产生、钙超载、线粒体功能障碍、细胞凋亡和自噬。已有研究表明白藜芦醇与阿霉素联合用药可以预防心脏毒性，并且对肿瘤细胞发挥协同治疗效应。主要对白藜芦醇的心脏毒性保护作用进行综述，阐明白藜芦醇在阿霉素诱导心脏毒性中保护作用的机制。

Adriamycin is a major therapeutic agent for a variety of hematological malignancies and solid tumors. However, its clinical application is limited by dose-dependent cardiotoxicity. The mechanism of doxorubicin-induced cardiotoxicity may involve multiple signaling pathways, including free radical production, calcium overload, mitochondrial dysfunction, apoptosis and autophagy. Studies have shown that resveratrol combined with doxorubicin has been reported to prevent cardiac toxicity, and play a synergistic effect on tumor cells. The protective effect of resveratrol on cardiac toxicity is reviewed in this paper, and the protective mechanism of resveratrol in adriamycin-induced cardiotoxicity is also elucidated.