目的 探讨复方甘草酸苷片联合枸地氯雷他定片治疗慢性特发性荨麻疹的临床疗效。方法 选取2015年1月—2016年3月赤峰市医院皮肤科收治的慢性特发性荨麻疹患者124例，随机分为对照组和治疗组，每组各62例。对照组口服枸地氯雷他定片，1片/次，1次/d。治疗组在对照组基础上餐后口服复方甘草酸苷片，50 mg/次，3次/d。两组患者均连续治疗28 d。观察两组的临床疗效，比较两组的症状评分、细胞因子和抗体免疫球蛋白E（IgE）。结果 治疗后，对照组和治疗组的总有效率分别为75.81%、91.94%，两组比较差异有统计学意义（P < 0.05）。治疗后，两组瘙痒程度、风团数量、风团直径、持续时间、发作次数、总评分均显著下降，同组治疗前后比较差异有统计学意义（P < 0.05）；且治疗组这些观察指标的下降程度明显优于对照组，两组比较差异具有统计学意义（P < 0.05）。治疗后，两组白细胞介素-2（IL-2）、白细胞介素-12（IL-12）、γ-干扰素（IFN-γ）水平显著升高，而白细胞介素-4（IL-4）、白细胞介素-8（IL-8）、IgE水平显著降低，同组治疗前后比较差异有统计学意义（P < 0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P < 0.05）。结论 复方甘草酸苷片联合枸地氯雷他定片治疗慢性特发性荨麻疹具有较好的临床疗效，能改善临床症状，升高IL-2、IL-12、IFN-γ水平，降低IL-4、IL-8、IgE水平，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Compound Glycyrrhizin Tablets combined with Desloratadine Citrate Disodium Tablets in treatment of chronic idiopathic urticaria. Methods Patients (124 cases) with chronic idiopathic urticaria in Department of Dermatology of Chifeng Municipal Hospital from January 2015 to March 2016 were randomly divided into control and treatment groups, and each group had 62 cases. Patients in the control group were po administered with Desloratadine Citrate Disodium Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Compound Glycyrrhizin Tablets on the basis of the control group after meal, 50 mg/time, three times daily. Patients in two groups were treated for 28 d. After treatment, the clinical efficacies were evaluated, and symptom scores, cytokines, and antibody IgE in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 75.81% and 91.94%, respectively, and there was difference between two groups (P < 0.05). After treatment, pruritus, wheal number, wheal diameter, duration, seizure frequency, and total score in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, IL-2, IL-12, and IFN-γ levels in two groups were significantly increased, but IL-4, IL-8, and IgE levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Compound Glycyrrhizin Tablets combined with Desloratadine Citrate Disodium Tablets has clinical curative effect in treatment of chronic idiopathic urticaria, can improve clinical symptoms, can increase the levels of IL-2, IL-12, and IFN-γ, and decrease the levels of IL-4, IL-8, and IgE, which has a certain clinical application value.