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[摘要]
目的 探讨定坤丹联合来曲唑治疗不孕症的临床疗效。方法 选取2013年3月—2015年3月在南阳市卧龙区第一人民医院接受诊治的不孕症患者76例,随机分为对照组和治疗组,每组各38例。对照组患者于月经结束后3 d开始口服来曲唑片,1片/次,2次/d。治疗组在对照组的基础上口服定坤丹,1丸/次,2次/d。两组患者均连续服用至下次月经前2周,连续服用4个月。评价两组患者妊娠率,同时比较两组治疗前后子宫内膜厚度、成熟卵泡数、性激素水平和生活质量评分变化。结果 治疗后对照组的妊娠率为60.53%,显著低于治疗组的81.58%,两组妊娠率比较差异有统计学意义(P < 0.05)。治疗后,两组患者子宫内膜厚度、成熟卵泡数均高于治疗前(P < 0.05);且与对照组相比,治疗组患者升高的更显著(P < 0.05)。治疗后,两组患者血清促黄体生成素(LH)显著升高,卵泡生成激素(FSH)和催乳素(PRL)水平显著降低,同组治疗前后比较差异具有统计学意义(P < 0.05);且治疗组患者这些性激素水平改善优于对照组,两组比较差异具有统计学意义(P < 0.05)。治疗后,两组各项生活质量评分显著升高P < 0.05);且治疗组患者这些生活质量评分均高于对照组,(P < 0.05)。结论 定坤丹联合来曲唑治疗不孕症效果显著,可明显改善机体性激素水平,提高患者生活质量,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical efficacy of Dingkundan combined with letrozole in treatment of infertility. Methods Patients (76 cases) with infertility in Wolong District First People's Hospital of Nanyang from March 2013 to March 2015 were randomly divided into control and treatment groups, and each group had 63 cases. Patients in the control group were po administered with Letrozole Tablets 3 d after menstruation, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Dingkundan on the basis of the control group, 1 pill/time, twice daily. Patients in two groups were treated for two weeks before the next menstrual period, and continually treated for four months. After treatment, the pregnancy rate was evaluated, and the endometrial thickness, the number of mature follicles, sex hormone levels, and quality of life scores in two groups were compared. Results After treatment, the pregnancy rate in the control group was 60.53%, which was significantly lower than 81.58% in the treatment group, with significant difference between two groups (P < 0.05). After treatment, the endometrial thickness and the number of mature follicles in two groups significantly increased (P < 0.05). And compared with the control group, the two indexes in the treatment group were significantly higher than those in the control group (P < 0.05). After treatment, the serum LH in two groups significantly increased, but the FSH and PRL significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And these sex hormone levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the life quality scores in two groups significantly increased (P < 0.05). And the life quality scores in the treatment group were significantly higher than those in the control group (P < 0.05).Conclusion Dingkundan combined with letrozole has significant effect in treatment of infertility, can significantly improve the sexual hormone level and the life quality, which has a certain clinical application value.
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