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[摘要]
目的 探讨茜芷胶囊联合米非司酮治疗人流术后持续阴道出血的临床疗效。方法 选取深圳市龙华新区人民医院2013年3月—2016年3月收治的人流术后持续阴道流血患者161例,随机分成对照组(80例)和治疗组(81例)。对照组患者在常规治疗基础上口服米非司酮片,12.5 mg/次,1次/d。治疗组在对照组的基础上口服茜芷胶囊,5粒/次,3次/d。两组患者均连续治疗1周。比较治疗后两组患者临床疗效、宫腔内残留物、术后出血时间、术后阴道出血量、月经复潮时间以及不良反应发生率。结果 治疗后,对照组和治疗组的总有效率分别为81.25%、97.53%,两组比较差异具有统计学意义(P < 0.05)。治疗后,治疗组患者宫腔无残留物例数显著高于对照组患者,两组比较差异具有统计学意义(P < 0.05)。治疗后,治疗组患者术后阴道出血时间和术后阴道出血量分别显著低于对照组患者,两组比较差异具有统计学意义(P < 0.05)。治疗后,对照组的不良反应发生率为22.50%,显著高于治疗组的7.41%,两组比较差异具有统计学意义(P < 0.05)。结论 茜芷胶囊联合米非司酮治疗人流术后阴道出血不论是在临床疗效方面还是在不良反应发生率方面均要优于米非司酮单独治疗,具有一定的临床推广应用价值。
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[Abstract]
Objective To explore the clinical curative effect of Qianzhi Capsules combined with mifepristone in treatment of continuous vaginal hemorrhage after artificial abortion. Methods Patients (161 cases) with continuous vaginal hemorrhage after artificial abortion in People's Hospital of Longhua in Shenzhen from March 2013 to March 2016 were divided into control (80 cases) and treatment (81 cases) groups. Patients in the control group were po administered with Mifepristone Tablets, 12.5 mg/time, once daily. Patients in the treatment group were po administered with Qianzhi Capsules on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for one week. After treatment, the clinical efficacy, intrauterine residue, postoperative bleeding time, postoperative vaginal bleeding volume, menstruation recovery time, and adverse reactions in two groups after treatment were analyzed and compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.25% and 97.53% respectively, and there was difference between two groups (P < 0.05). After treatment, patients without intrauterine residue in the treatment group were significantly more than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the postoperative bleeding time and postoperative vaginal bleeding volume in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the adverse reactions rate in the control group was 22.50%, which was significantly higher than 7.41% in the treatment group, with significant difference between two groups (P < 0.05). Conclusion Qianzhi Capsules combined with mifepristone is better than mifepristone alone in aspects of clinical efficacy and adverse reactions rate in treatment of continuous vaginal hemorrhage, which has a certain clinical application value.
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