目的 探讨金水宝胶囊联合还原型谷胱甘肽治疗急性肾损伤的临床疗效。方法 选取2013年10月—2016年10月在重庆市开州区人民医院住院治疗的急性肾损伤患者78例，随机分为对照组和治疗组，每组各39例。对照组静脉滴注注射用还原型谷胱甘肽，1.2 g溶解在100 mL生理盐水中，1次/d。治疗组在对照组治疗基础上口服金水宝胶囊，4粒/次，3次/d。两组均连续治疗1个月。观察两组的临床疗效，比较两组少尿期和多尿期持续时间及血肌酐（Scr）恢复正常的时间。比较治疗前、治疗3、7、14、30 d两组Scr、内生肌酐清除率、尿渗透压、尿β₂-微球蛋白的变化情况。结果 治疗后，对照组和治疗组的总有效率分别为76.92%、92.31%，两组比较差异有统计学意义（P < 0.05）。治疗组的少尿期、多尿期的持续天数以及血肌酐恢复正常时间均显著短于对照组，两组比较差异有统计学意义（P < 0.05）。治疗后，两组Scr、尿β₂-微球蛋白从治疗第3天起显著降低，内生肌酐清除率、尿渗透压从治疗3 d开始显著升高，同组治疗前后差异有统计学意义（P < 0.05）；治疗组在治疗7、14、30天Scr低于对照组，内生肌酐清除率高于对照组；治疗组在治疗3、7、14、30天尿渗透压高于对照组，尿β2-微球蛋白低于对照组，两组比较差异有统计学意义（P < 0.05）。结论 金水宝胶囊联合还原型谷胱甘肽治疗急性肾损伤具有较好的临床疗效，可降低多尿期、少尿期及血肌酐恢复正常的时间，改善患者肾功能，具有一定的临床推广应用价值。

Objective To investigate the effect of Jinshuibao Capsules combined with reduced glutathione in treatment of acute kidney injury. Methods Patients (78 cases) with acute kidney injury in Kaizhou District People's Hospital in Chongqing from October 2013 to October 2016 were randomly divided into control and treatment groups, and each group had 39 cases. Patients in the control group were iv administered with Reduced Glutathione Sodium for injection, 1.2 g added into normal saline 100 mL, once daily. The patients in the treatment group were po administered with Jinshuibao Capsules, 4 grains/time, three times daily. The patients in two groups were treated for 1 month. After treatment, the efficacy was evaluated, and the low urinary time, multiple urine time and Scr recovery time in two groups were compared. The changes of Scr, endogenous creatinine clearance, urine osmotic pressure and urine β₂ microglobulin before treatment and the treatment of 3, 7, 14, and 30 d in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 76.92% and 92.31%, respectively, and there were differences between two groups (P < 0.05). The low urinary time, multiple urine time and Scr recovery time in treatment group were shorter than those in the control group, with significant difference between two groups (P < 0.05). After treatment, Scr and urine β₂ microglobulin in two groups significantly reduced since the third day of treatment, endogenous while endogenous creatinine clearance and urine osmotic pressure significantly increased since the third day of treatment, and the difference was statistically significant in the same group (P < 0.05). The level of Scr in the treatment group was lower than that in the control group on the treatment of 7, 14, and 30 d, and endogenous creatinine clearance rate was higher than that of the control group; Urine osmotic pressure was higher than that of the control group on the treatment for 3, 7, 14, and 30 d, β₂ microglobulin was lower than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Jinshuibao Capsules combined with reduced glutathione has clinical curative effect in treatment of acute kidney injury, and can decrease low urinary time, multiple urine time and Scr recovery time, and improve the kidney function, which has a certain clinical application value.