目的 探讨盐酸米诺环素软膏联合碘甘油治疗牙周炎的临床疗效。方法 选取2014年2月—2015年9月深圳市盐田区人民医院收治的90例牙周炎患者107颗患牙作为研究对象，根据序列号法分为对照组（45例，55颗）和治疗组（45例，52颗）。对照组在患牙牙周袋内注入碘甘油，用药1 h内禁饮食或漱口，1次/周。治疗组在对照组基础上在患牙牙周袋内注入盐酸米诺环素软膏，用药1 h内禁饮食或漱口，1次/周。两组患者均治疗4周。观察两组的临床疗效，比较两组的炎症指标和牙周指标情况。结果 治疗后，对照组和治疗组的总有效率分别为78.18%、96.15%，两组比较差异有统计学意义（P < 0.05）。治疗后，两组高敏C反应蛋白（hs-CRP）、肿瘤坏死因子α（TNF-α）、弹性蛋白酶（EA）和前列腺素E₂（PGE₂）水平均显著下降，同组治疗前后比较差异有统计学意义（P < 0.05）；且治疗组这些观察指标的下降程度明显优于对照组，两组比较差异具有统计学意义（P < 0.05）。治疗后，两组牙龈出血指数（GI）、牙齿松动度（MD）、牙周袋深度（PD）、牙周附着水平（AL）、牙槽骨吸收（ABL）均显著下降，同组治疗前后比较差异有统计学意义（P < 0.05）；且治疗组这些观察指标的下降程度明显优于对照组，两组比较差异具有统计学意义（P < 0.05）。结论 盐酸米诺环素软膏联合碘甘油治疗牙周炎具有较好的临床疗效，能降低炎症反应，改善牙周状况，促进牙周组织恢复，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of minocycline combined with Iodine Glycerol in treatment of periodontitis. Methods Patients (90 cases and 107 teeth) with periodontitis in Shenzhen Yantian District People's Hospital from February 2014 to September 2015 were divided into the control group (45 cases, 55 teeth) and treatment group (45 cases, 52 teeth) according to serial number method. Patients in the control group were injection administered with iodine glycerol in the periodontal bag, no diet or mouthwash within 1 h, once weekly. Patients in the treatment group were injection administered with Minocycline Hydrochloride Ointment in the periodontal bag on the basis of the control group, no diet or mouthwash within 1 h, once weekly. Patients in two groups were treated for four weeks. After treatment, the clinical efficacies were evaluated, and inflammation indexes and periodontal indexes were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.18% and 96.15%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of hs-CRP, TNF-α, EA and PGE₂ levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, GI, MD, PD, AL and ABL in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Minocycline Hydrochloride Ointment combined with iodine glycerol has clinical curative effect in treatment of periodontitis, can decrease inflammatory response, improve periodontal status, and promote periodontal tissue recovery, which has a certain clinical application value.