目的 探讨鼻渊通窍颗粒联合莫西沙星治疗急性鼻窦炎的临床疗效。方法 选取2015年10月—2016年10月在南方医科大学南方医院接收治疗的急性鼻窦炎患者150例，随机分为对照组（75例）和治疗组（75例）。对照组患者口服盐酸莫西沙星片，1片/次，1次/d。治疗组在对照组的基础上口服鼻渊通窍颗粒，1袋/次，3次/d。两组患者均治疗14 d。比较两组患者临床疗效、临床症状评分和血清炎性因子水平。结果 治疗后，对照组和治疗组的总有效率分别为81.33%、96.00%，两组总有效率比较差异有统计学意义（P < 0.05）。治疗后，两组患者鼻塞、鼻涕和头痛评分均较治疗前明显降低，同组比较差异具有统计学意义（P < 0.05）；且治疗组比对照组降低更显著，两组比较差异具有统计学意义（P < 0.05）。与治疗前相比，治疗后两组患者血清超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平明显降低，而IL-10水平明显升高，同组比较差异具有统计学意义（P < 0.05）；且治疗组上述血清炎性因子水平改善更明显，两组比较差异具有统计学意义（P < 0.05）。结论 鼻渊通窍颗粒联合莫西沙星治疗急性鼻窦炎的临床效果显著，可明显改善患者临床症状和降低血清炎性因子，具有一定的临床推广应用价值。

Objective To evaluate the clinical efficacy of Biyuan Tongqiao Granules combined with moxifloxacin in treatment of acute sinusitis. Methods Patients (150 cases) with acute sinusitis in Nanfang Hospital of Southern Medical University from October 2015 to October 2016 were randomly divided into control (75 cases) and treatment (75 cases) groups. Patients in the control group were po administered with Moxifloxacin Hydrochloride Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Biyuan Tongqiao Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy, clinical symptom scores, and serum inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.33% and 96.00% respectively, and there was difference between two groups (P < 0.05). After treatment, the nasal congestion, runny nose, and headache scores in two groups significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And these clinical symptom scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Compared with those before treatment, the hs-CRP, IL-6, and TNF-α levels in two groups significantly decreased, but the IL-10 level significantly increased, and the difference was statistically significant in the same group (P < 0.05). And these serum inflammatory factors levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Biyuan Tongqiao Granules combined with moxifloxacin has significant clinical effect in treatment of acute sinusitis, can significantly improve the clinical symptoms and reduce the serum inflammatory factors, which has a certain clinical application value.