目的 探讨双环醇联合还原型谷胱甘肽治疗抗结核药物性肝炎患者的临床疗效。方法 收集2012年2月—2016年2月常州市第三人民医院收治的抗结核药物性肝炎患者78例，随机分为对照组和治疗组，每组各39例，对照组患者在常规治疗的基础上静脉滴注注射用还原型谷胱甘肽，1.8 g加入到5%葡萄糖注射液250 mL中，1次/d。治疗组患者在对照组的基础上口服双环醇片，25 mg/次，3次/d，两组患者均连续治疗30 d。治疗后，比较两组患者的临床疗效、肝功能指标的变化、超氧化物歧化酶（SOD）、丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Px）和不良反应。结果 治疗后，对照组和治疗组的总有效率分别为76.92%、100.00%，两组总有效率比较差异有统计学意义（P < 0.05）。两组患者的肝功能指标水平均比治疗前明显降低，同组治疗前后比较差异具有统计学意义（P < 0.05）；且治疗组的肝功能指标水平明显低于对照组，两组比较差异具有统计学意义（P < 0.05）。两组患者SOD和GSH-Px水平均较治疗前显著升高，MDA水平降低，同组治疗前后比较差异具有统计学意义（P < 0.05）；且治疗组的上述观察指标的改善明显优于对照组，两组比较差异具有统计学意义（P < 0.05）。两组的不良反应发生率比较差异无统计学意义。结论 双环醇联合还原型谷胱甘肽治疗抗结核药物性肝炎临床疗效显著，能明显改善患者的肝功能，具有一定的临床推广应用价值。

Objective To explore the clinical efficacy of bicyclol combined with reduced glutathione in treatment of anti-tuberculosis drug-induced hepatitis. Methods Patients (78 cases) with anti-tuberculosis drug-induced hepatitis in Changzhou Third People's Hospital from February 2012 to February 2016 were randomly divided into control and treatment groups, and each group had 39 cases. Patients in the control group were iv administered with Reduced Glutathione for injection on the basis of conventional therapy, 1.8 g added into 5% glucose injection 250 mL, once daily. Patients in the treatment group were po administered with Bicyclol Tablets, 25 mg/time, three times daily. Patients in two groups were treated for 30 d. After treatment, the clinical efficacy was evaluated, and the changes of liver function indexes, superoxide dismutase (SOD), methane dicarboxylic aldehyde (MDA), glutathione peroxidase (GSH-Px), and adverse reactions were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.92% and 100.00%, respectively, and there was difference between two groups (P < 0.05). Liver function indexes levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). Liver function indexes levels in the treatment were lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, SOD and GSH-Px levels in two groups were significantly increased, but MDA level was decreased, and there was difference in the same group (P < 0.05). And these indexes in the treatment group were significantly better than those in the control group (P < 0.05). There was no significant difference in adverse reactions between two groups. Conclusion Bicyclol combined reduced glutathione has clinical curative effect in treatment of anti-tuberculosis drug-induced hepatitis, and can significantly improve liver function, which has a certain clinical application value.