目的 探讨注射用红花黄色素联合注射用盐酸替罗非班治疗急性冠状动脉综合征的安全性和有效性。方法 选取2015年9月—2016年9月平煤神马医疗集团总医院心血管内科收治的急性冠状动脉综合征患者197例，随机分成对照组（98例）和治疗组（99例）。对照组静脉滴注注射用盐酸替罗非班，12.5 mg加入到0.9%氯化钠注射液500 mL中，起始剂量为0.4 μg/(kg·min)，静脉滴注1 h，然后以0.1 μg/(kg·min)的剂量进行维持治疗72 h。治疗组在对照组基础上静脉滴注注射用红花黄色素，100 mg加入到0.9%氯化钠注射液250 mL中，1次/d。所有患者均连续治疗14 d。观察两组的临床疗效，比较两组的心功能指标、超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、基质金属蛋白酶-9（MMP-9）、不良心血管事件情况。结果 治疗后，对照组和治疗组的总有效率分别为85.71%、94.95%，两组比较差异有统计学意义（P < 0.05）。治疗后，两组左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）、左房舒张末期内径（LADD）和左室射血分数（LVEF）均显著升高，同组治疗前后比较差异有统计学意义（P < 0.05）；且治疗组这些观察指标的升高程度明显优于对照组，两组比较差异具有统计学意义（P < 0.05）。治疗后，两组hs-CRP、IL-6和MMP-9水平显著下降，同组治疗前后比较差异有统计学意义（P < 0.05）；且治疗组这些观察指标的下降程度明显优于对照组，两组比较差异具有统计学意义（P < 0.05）。治疗1个月后，对照组和治疗组不良心血管事件发生率分别为17.35%、6.06%，两组比较差异具有统计学意义（P < 0.05）。结论 注射用红花黄色素联合注射用盐酸替罗非班治疗急性冠状动脉综合征具有较好的临床疗效，可改善心功能指标，调节hs-CRP、IL-6和MMP-9水平，降低不良心血管事件，安全性较好，具有一定的临床推广价值。

Objective To explore the safety and efficacy of Safflower yellow for injection combined with Tirofiban Hydrochloride for injection in treatment of acute coronary syndrome. Methods Patients (197 cases) with cerebral infarction in Department of Cardiovascular Medicine of Pingdingshan Shenma Medical Group General Hospital from September 2015 to September 2016 were randomly divided into the control group (98 cases) and the treatment group (99 cases). Patients in the control group were iv administered with Tirofiban Hydrochloride for injection, 12.5 mg added into normal saline 500 mL, starting dosage 0.4 μg/(kg·min) for 1 h, then maintenance dosage 0.1μg/(kg·min) for 72 h. Patients in the treatment group were iv administered with Safflower yellow for injection on the basis of the control group, 100 mg added into normal saline 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and heart function indexes, hs-CRP, IL-6, MMP-9, and adverse cardiovascular events in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.71% and 94.95%, respectively, and there was difference between two groups (P < 0.05). After treatment, LVEDD, LVESD, LADD, and LVEF in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of hs-CRP, IL-6, and MMP-9 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment for one month, the adverse cardiovascular events in the control and treatment groups were 17.35% and 6.06%, respectively, and there was difference between two groups (P < 0.05). Conclusion Safflower yellow for injection combined with Tirofiban Hydrochloride for injection has clinical curative effect in treatment of acute coronary syndrome, can improve heart function, regulate the levels of hs-CRP, IL-6, and MMP-9, and decrease adverse cardiovascular events, with good safety, which has a certain clinical application value.