目的 制备1,3-二羟基异丙氧基-琥珀酸-8-莪术醇酯纳米混悬剂（Cur-p-NS），并考察其一般特性、载药量和体外释放特性。方法 采用超声–溶剂沉淀法制备Cur-p-NS，考察其粒度大小，多聚分散系数和Zeta电位。结果 Cur-p-NS的平均粒径为162.60±2.12 nm，多分散系数为0.182±0.002，Zeta电位为-24.60±8.97 mV，平均载药量为0.942 mg/mg，累积释放率可达到77%。结论 Cur-p-NS制备工艺简单和效果好，具有持续释放的特性。

Objective To prepare 1, 3-dihydroxyisopropoxy-succinic acid-8-curcumol ester nanosuspensions (Cur-p-NS) and study their general characteristics, drug loading, and drug release characteristics in vitro. Methods Cur-p-NS was prepared by ultrasonic- solvent precipitation. And the particle size, polydispersion index, and Zeta potential of the nanosuspension were studied. Results The particle size, polydispersion index, Zeta potential,the drug-loading content, and the cumulative release rate of the nanosuspension were 162.60 ± 2.12 nm, 0.182 ± 0.002, -24.60 ± 8.97 mV, 0.942 mg/mg, and 77%, respectively. Conclusion Cur-p-NS has simple preparation and good effect, which has characteristic of sustained release.

国家自然科学基金资助项目（81302656）；中国医学科学院医学与健康科技创新工程经费资助项目（2016-I2M-1-012）