目的 了解解放军总医院海南分院质子泵抑制剂（PPIs）的使用情况，为合理使用和管理提供参考。方法 收集解放军总医院海南分院2013-2015年PPIs的相关使用数据，并分析其变化趋势。结果 PPIs的用药金额及其占总用药金额的比例均逐年增长；PPIs用药金额排前3位科室分别为消化内科、急诊科和肿瘤科；门诊和住院PPIs用药金额及使用率均逐年增长；口服剂型PPIs用药金额逐年增长，但构成比逐年下降，而注射剂型PPIs用药金额及构成比均逐年增长；注射用兰索拉唑、注射用埃索美拉唑钠的DDDs、用药金额和构成比均逐年增长，而注射用泮托拉唑钠和注射用奥美拉唑钠DDDs、用药金额和构成比均逐年下降。结论 解放军总医院海南分院绝大部分PPIs的用药金额和使用率均呈持续上升趋势，应及时把握用药现状，规范合理用药。

Objective To investigate the use of proton pump inhibitors (PPIs) in Hainan Branch of PLA General Hospital, so as to provide reference for the rational use and better management of PPIs. Methods The data of the clinical use of PPIs were collected in Hainan Branch of PLA General Hospital from 2013 to 2015, and then the change trend of the application of PPIs was analyzed. Results The consumption sum of PPIs and the ratio to total cost of drugs raised year by year. The top 3 departments of PPIs cost were Department of Digestive, Emergency, and Oncology. The consumption sum and the usage rate of PPIs for inpatients and outpatients were increased year by year. The cost of PPIs for oral was increased, but the proportion was decreased yearly. While both the cost and proportion of PPIs for injection were increased yearly. DDDs, consumption sum and the constituent ratio of Lansoprazole for injection and Esomeprazole Sodium for injection were increased yearly. However, those of Pantoprazole Sodium for injection and Omeprazole Sodium for injection were reduced yearly. Conclusion The consumption sum and usage rate of most PPIs in Hainan Branch of PLA General Hospital both show a trend of rising, therefore current situation of drug application should be grasped timely, in order to standardize the rational use of drugs.