目的 分析2014-2016年北京大学深圳医院曲美他嗪处方的使用情况，为促进临床合理用药提供依据。方法 抽取2014-2016年北京大学深圳医院使用曲美他嗪的处方，并进行回顾性分析。结果 2015年处方量变化不大，但2016年处方量明显下降。2014-2016年开具曲美他嗪处方的科室类别和排名变化不大，主要是心血管内科、特诊老年病科。2016年超适应症用药处方量明显减少，但禁忌症使用人次明显高于2014、2015年。结论 曲美他嗪在临床上仍然存在不合理用药情况，需要更多的研究以助于科学地评估和分析效益-风险比。

Objective To analyze the utilization of trimetazidine prescription in Peking University Shenzhen Hospital from 2014 to 2016. Methods Trimetazidine prescription in Peking University Shenzhen Hospital from 2014 to 2016 was extracted and analyzed retrospectively. Results The quantity of trimetazidine prescription in 2015 was near to that in 2014, but the amount of prescriptions was obviously decreased in 2016. The category and rank of department had little change from 2014 to 2016, and the trimetazidine prescription was chiefly prescribed by the departments of cardiovascular medicine and special clinic geriatrics. The prescription amount of off-label use was obviously decreased in 2016, while the number of contraindication was obviously higher than that in 2014 and 2015. Conclusions There is still some irrational drug use in clinic, therefore more researches are needed for evaluation on benefit-risk balance.