目的 探讨硝呋太尔胶囊联合盐酸环丙沙星栓治疗细菌性阴道炎的临床疗效。方法 选取2014年4月-2016年4月在乐东黎族自治县第二人民医院接受诊治的细菌性阴道炎患者84例，按照治疗方法的差别分成对照组和治疗组，每组各42例。对照组睡前清洁外阴后给予盐酸环丙沙星栓，1粒放置阴道深部，1次/d。治疗组在对照组基础上口服硝呋太尔胶囊，2粒/次，3次/d。两组患者均治疗14 d。观察两组的临床疗效，比较两组的临床症状消失时间、阴道灌洗液炎性因子和血清氧化应激产物情况。结果 治疗后，对照组和治疗组的总有效率分别为80.95%、95.24%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组白带减少时间、外阴瘙痒消失时间、外阴阴道疼痛消失时间、黏膜充血消失时间均较对照组明显缩短，两组比较差异具有统计学意义（P<0.05）。治疗后，两组阴道灌洗液中白细胞介素-2（IL-2）、白细胞介素-8（IL-8）和白细胞介素-13（IL-13）水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的下降程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清丙二醛（MDA）和内皮素-1（ET-1）水平均显著降低，而超氧化物歧化酶（SOD）和一氧化氮（NO）水平均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 硝呋太尔胶囊联合盐酸环丙沙星栓治疗细菌性阴道炎具有较好的临床疗效，可明显改善临床症状，降低炎性因子和氧化应激产物水平，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Nifuratel Capsules combined with Ciprofloxacin Hydrochloride Suppositories in treatment of bacterial vaginitis. Methods Patients (84 cases) with bacterial vaginitis in the Second People's Hospital of Ledong Li Nationality Autonomous County from April 2014 to April 2016 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 42 cases. Patients in the control group were given Ciprofloxacin Hydrochloride Suppositories after cleaning the vulva before bedtime, 1 grain placed into the vagina deep, once daily. Patients in the treatment group were po administered with Nifuratel Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and clinical symptom disappearance time, vaginal lavage fluid inflammatory factors, and serum oxidative stress products in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.95% and 95.24%, respectively, and there was difference between two groups (P<0.05). After treatment, the disappeared times of leucorrhea reduced, genital itching, vaginal pain, and mucosal congestion in the treatment group were shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of IL-2, IL-8, and IL-13 in vaginal lavage fluid in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of MDA and ET-1 in two groups were significantly decreased, but the levels of SOD and NO in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Nifuratel Capsules combined with Ciprofloxacin Hydrochloride Suppositories has clinical curative effect in treatment of bacterial vaginitis, can improve clinical symptoms, and decrease the levels of inflammatory factors and oxidative stress products, which has a certain clinical application value.