目的 探讨妇炎灵胶囊联合盐酸克林霉素乳膏和甲硝唑片治疗细菌性阴道炎的临床疗效。方法 选取2015年7月-2016年7月在澄迈县人民医院接受诊治的细菌性阴道炎患者86例，按照治疗方法的差别分成对照组和治疗组，每组各43例。对照组口服甲硝唑片，0.4 g/次，2次/d；睡前清洁外阴后阴道内涂抹盐酸克林霉素乳膏，1次/d。治疗组在对照组基础上于睡前在阴道后穹隆放置妇炎灵胶囊，2粒/次，1次/d。两组患者均治疗7 d。观察两组的临床疗效，比较两组的临床症状消失时间、阴道灌洗液炎性因子和血清氧化应激产物情况。结果 治疗后，对照组和治疗组的总有效率分别为81.40%、95.35%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组白带减少时间、外阴瘙痒消失、外阴阴道疼痛消失和黏膜充血消失时间均较对照组明显缩短，两组比较差异具有统计学意义（P<0.05）。治疗后，两组阴道灌洗液中白细胞介素-2（IL-2）、白细胞介素-6（IL-6）和白细胞介素-8（IL-8）水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的下降程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清丙二醛（MDA）水平均显著降低，而超氧化物歧化酶（SOD）和一氧化氮（NO）水平均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 妇炎灵胶囊联合盐酸克林霉素乳膏和甲硝唑片治疗细菌性阴道具有较好的临床疗效，可明显改善临床症状，降低炎性因子和氧化应激产物水平，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Fuyanling Capsules combined with Clindamycin Hydrochloride Cream and Metronidazole Tablets in treatment of bacterial vaginitis. Methods Patients (86 cases) with bacterial vaginitis in Chengmai County People's Hospital from July 2015 to July 2016 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were po administered with Metronidazole Tablets, 0.4 g/time, twice daily. And they were daub administered with Clindamycin Hydrochloride Cream inside the vagina after cleaning the vulva before bedtime, once daily. Patients in the treatment group were placed with Fuyanling Capsules in the posterior fornix of vagina before bedtime on the basis of the control group, 2 grains/time, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and clinical symptom disappearance time, vaginal lavage fluid inflammatory factors, and serum oxidative stress products in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.40% and 95.35%, respectively, and there was difference between two groups (P<0.05). After treatment, the times of leucorrhea reduced, genital itching disappeared, vaginal pain disappeared, and mucosalcongestion disappeared in the treatment group were shorter than those in the control groups, and there was difference between two groups (P<0.05). After treatment, the levels of IL-2, IL-6, and IL-8 in vaginal lavage fluid in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of MDA in two groups were significantly decreased, but the levels of SOD and NO were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Fuyanling Capsules combined with Clindamycin Hydrochloride Cream and Metronidazole Tablets has clinical curative effect in treatment of bacterial vaginitis, can improve clinical symptoms, and decrease the levels of inflammatory factors and oxidative stress products, which has a certain clinical application value.