目的 探究氨溴索口服液联合酮替芬治疗小儿哮喘的临床疗效。方法 选取2013年1月-2015年1月在三六三医院接受治疗的小儿哮喘患儿83例，随机分为对照组（41例）和治疗组（42例）。对照组患儿口服富马酸酮替芬片，3岁以下患儿0.5 mg/次，2次/d；3岁以上1 mg/次，2次/d。治疗组患儿在对照组的基础上口服盐酸氨溴索口服液，1～2岁患儿2.5 mL/次，2次/d；2～6岁2.5 mL/次，3次/d；6～12岁5 mL/次，2～3次/d。两组患儿均连续治疗6周。观察两组患儿临床疗效，同时比较两组患儿治疗前后平喘时间、止咳时间、咳痰和肺部哮鸣音消失时间及症状复发率。结果 治疗后，对照组和治疗组的总有效率分别为73.17%、95.23%，两组总有效率比较差异有统计学意义（P<0.05）。治疗后，治疗组患儿的平喘时间、咳痰时间、止咳时间和肺部哮鸣音消失时间均显著短于对照组，两组比较差异有统计学意义（P<0.05）。治疗组3、6个月的复发率分别为2.3%、7.0%，显著低于同期对照组的复发率，两组比较差异有统计学意义（P<0.05）。结论 氨溴索口服液联合酮替芬治疗小儿哮喘可显著缩短患儿平喘时间，止咳快且哮鸣音消失时间短，复发率低，具有一定的临床推广应用价值。

Objective To observe the curative effect of ambroxol oral solution combined with ketotifen in treatment of children asthma. Methods Children (83 cases) with asthma in 363 Hospital from January 2013 to January 2015 were randomly divided into control (41 cases) and treatment (42 cases) groups. Children in the control group were po administered with Ketotifen Fumarate Tablets, 0.5 mg/time for children under 3 years old, twice daily, and 1 mg/time for children above 3 years old, twice daily. Children in the treatment group were po administered with Ambroxol Hydrochloride Oral Solution on the basis of the control group, 2.5 mL/time for 1-2 years old children, twice daily. And 2.5 mL/time for 2-6 years old children, three times daily. And 5 mL/time for 6-12 years old children, 2-3 times daily. Children in two groups were treated for 6 weeks. After treatment, the clinical efficacy was evaluated, and the disappearing time of asthma, cough, expectoration, and lung rale in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 73.17% and 95.23%, respectively, and there was difference between two groups (P<0.05). After treatment, the disappearing time of asthma, cough, expectoration, and lung rale in treatment group were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). The 3 and 6 months recurrence rate of the treatment group were 2.3% and 7.0%, which were significantly lower than that in the same period of the control group, with significant difference between two groups (P<0.05). Conclusion Ambroxol oral solution combined with ketotifen in treatment of children asthma can significantly shorten the time of asthma, cough and wheezing with low recurrence rate, which has a certain clinical application value.