目的 探究心脑宁胶囊联合氯吡格雷治疗不稳定型心绞痛的临床疗效。方法 选取2015年1月-2016年7月在华中科技大学附属协和医院西院接受治疗的不稳定型心绞痛患者96例，随机分成对照组和治疗组，每组各48例。对照组口服硫酸氢氯吡格雷片，首剂量300 mg，1次/d，症状减轻后75 mg/次，1次/d。治疗组在对照组的基础上口服心脑宁胶囊，2～3粒/次，3次/d。两组患者均连续治疗8周。比较两组患者治疗前后临床疗效、心绞痛发作频率和持续时间、硝酸甘油日耗量、血清超敏C-反应蛋白（hs-CRP）和白介素-6（IL-6）水平。结果 治疗后，对照组的总有效率为79.17%，显著低于治疗组的91.67%，两组总有效率比较差异有统计学意义（P<0.05）。治疗后，两组患者心绞痛发作频率、持续时间和硝酸甘油的日消耗量均显著下降，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组患者比对照组降低更明显，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者血清hs-CRP和IL-6均显著降低，同组比较差异具有统计学意义（P<0.05）；且治疗组患者上述指标改善明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 心脑宁胶囊联合氯吡格雷治疗不稳定型心绞痛能够使患者心绞痛发作频率和持续时间降低，同时可减少硝酸甘油日耗量，具有一定的临床推广应用价值。

Objective To explore the curative effect of Xinnaoning Capsules combined with clopidogrel in treatment of unstable angina pectoris. Methods Patients (96 cases) with unstable angina pectoris in the West Hospital of Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology from January 2015 to July 2016 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were po administered with Clopidogrel Bisulfate Tablets, the first dosage was 300 mg, and 75 mg/time after symptom decreased, once daily. Patients in the treatment group were po administered with Xinnaoning Capsules on the basis of the control group, 2-3 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy, the frequency and duration of angina pectoris, nitroglycerin daily consumption, hs-CRP and IL-6 levels in two groups were compared. Results After treatment, the clinical efficacy in the control group was 79.17%, which was significantly lower than 91.67% in the treatment group, with significant difference between two groups (P<0.05). After treatment, the frequency and duration of angina pectoris, and nitroglycerin daily consumption in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And these indicators levels in the treatment group were decreased more significantly than those in the control group, with significant difference between two groups (P<0.05). After treatment, the serum hs-CRP and IL-6 levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And these indicators levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xinnaoning Capsules combined with clopidogrel can reduce the frequency and duration of angina pectoris in treatment of unstable angina pectoris with decreasing nitroglycerin daily consumption, which has a certain clinical application value.