目的 观察安神补脑液联合舍曲林治疗脑梗死后睡眠障碍的临床疗效。方法 选取2015年7月-2016年6月重庆市开州区人民医院收治的112例脑梗死后睡眠障碍患者随机分为对照组和治疗组，每组各56例。对照组患者口服盐酸舍曲林片，1片/次；治疗组在对照组治疗基础上口服安神补脑液，10 mL/次，2次/d。两组疗程均为4周。观察两组的临床疗效，比较两组治疗前后匹兹堡睡眠质量指数（PSQI）、阿森斯失眠量表（AIS）评分、美国国立卫生研究院卒中量表（NIHSS）评分、汉密尔顿抑郁量表（HAMD）评分，睡眠状况相关指标。结果 治疗后，对照组和治疗组的总有效率分别为71.43%、91.07%，两组比较差异有统计学意义（P<0.05）。治疗后，两组PSQI评分、AIS评分、NIHSS评分、HAMD评分均显著降低，同组治疗前后差异有统计学意义（P<0.05）；治疗后，治疗组PSQI评分、AIS评分、NIHSS评分、HAMD评分低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组睡眠总时间、睡眠效率均较治疗前显著提高，夜间觉醒次数减少，同组治疗前后差异有统计学意义（P<0.05）；治疗后，治疗组睡眠总时间、睡眠效率高于对照组，夜间觉醒次数少于对照组，两组比较差异有统计学意义（P<0.05）。结论 安神补脑液联合舍曲林治疗脑梗死后睡眠障碍，临床疗效确切，患者睡眠质量改善明显，具有一定的临床推广应用价值。

Objective To observe the clinical effect of Anshen Bunao Liquid combined with sertraline in treatment of sleep disorder after stroke. Methods Patients (112 cases) with sleep disorder after stroke in Kaizhou District People's Hospital of Chongqing City from July 2015 to June 2016 were randomly divided into control and treatment groups, and each group had 56 cases. Patients in the control group were po administered with Sertraline Hydrochloride Tablets, 1 tablet/time. Patients in the treatment group were po administered with Anshen Bunao Liquid on the basis of the control group, 10 mL/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the efficacy was evaluated, and the scores of PSQI, AIS, NIHSS, and HAMD, and sleep related indicators before and after treatment in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 71.43% and 91.07%, respectively, and there were differences between two groups (P<0.05). After treatment, PSQI score, AIS score, NIHSS score, and HAMD score in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, PSQI score, AIS score, NIHSS score, and HAMD score in the treatment group were lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the total sleep time and sleep efficiency were significantly higher than those in the same group before treatment, and wake up times at night were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the total sleep time and sleep efficiency in the treatment were higher than those in the control group, and wake up times at night were less than those in the control group, and there were differences between two groups (P<0.05). Conclusion Anshen Bunao Liquid combined with sertraline has clinical curative effect in treatment of sleep disorder after stroke, and can improve sleep quality obviously, which has a certain clinical application value.