目的 观察天麻钩藤颗粒联合左旋多巴治疗帕金森病的临床疗效。方法 选取2015年7月-2016年6月监利县人民医院收治的帕金森患者88例，随机分为对照组和治疗组，每组各44例。对照组口服左旋多巴片，125 mg/次，2次/d，每周调整药物用量，逐渐增量至250 mg/次，3次/d，每日总剂量不超过6 g；治疗组在对照组的基础上口服天麻钩藤颗粒，5 g/次，3次/d。两组均治疗3个月。治疗后，观察两组的临床疗效，比较两组日常生活能力和运动能力评分和不良反应情况。结果 治疗后，对照组和治疗组的总有效率分别为61.36%、72.27%，两组比较差异有统计学意义（P<0.05）。治疗后，两组日常生活能力和运动能力评分均显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些评分明显低于对照组，两组比较差异具有统计学意义（P<0.05）。两组不良反应发生率比较差异无统计学意义。结论 天麻钩藤颗粒联合左旋多巴治疗帕金森病，临床疗效确切，症状改善明显，值得临床推广。

Objective To observe the clinical effect of Tianma Gouteng Granules combined with levodopa in treatment of Parkinson's disease. Methods Patients (88 cases) with Parkinson's disease in Jianli People's Hospital from July 2015 to June 2016 were randomly divided into control and treatment groups, and each group had 44 cases. Patients in the control group were po administered with Levodopa Tablets, 125 mg/time, twice daily. The dosage was adjusted every week, and was increased to 250 mg/time, three times daily. The total dosage was not more than 6 g/d. Patients in the treatment group were po administered with Tianma Gouteng Granules on the basis of the control group, 5 g/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and daily life ability and movement ability scores, and adverse reactions in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 61.36% and 72.27%, respectively, and there was difference between two groups (P<0.05). After treatment, daily life ability and movement ability scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And these scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). There was no significant difference in adverse reactions between two groups. Conclusion Tianma Gouteng Granules combined with levodopa has clinical curative effect in treatment of Parkinson's disease, and can improve symptoms significantly, which has a certain clinical application value.