目的 分析2013-2016年郑州市妇幼保健院妇科清洁手术预防用抗菌药物的使用情况，为进一步规范抗菌药物合理应用提供参考。方法 对2013年1月-2016年2月妇科清洁手术预防用抗菌药物的使用情况进行回顾性调查，并评价其合理性。结果 1 560例患者中，780例预防用抗菌药物，抗菌药物使用率为50.0%。用药维持时间以48、72 h为主，构成比分别为50.0%、39.5%。共涉及9个品种，头孢呋辛、甲硝唑和头孢西丁使用频次居前3位。术前0.5~1.0 h给药的例数最多，构成比为77.3%。不合理用药表现形式主要有用药指征把握不严（31.4%）、用药维持时间长（28.7%）、品种选择不当（17.6%）等。结论 郑州市妇幼保健院妇科清洁手术预防用抗菌药物使用基本合理，但仍存在不合理用药现象，应加强监督管理。

Objective To evaluate the use of antibacterial drugs in gynecological aseptic operations in Women and Infants Hospital of Zhengzhou from 2013 to 2016, and to provide reference for the further application of antibacterial drugs. Methods The use of prophylactic antibacterial drugs in gynecological aseptic operations in Women and Infants Hospital of Zhengzhou from January 2013 to February 2016 were analyzed statistically, and the rationality was evaluated. Results There were 780 cases of patients using prophylactic antibacterial drugs in 1 560 patients, and the usage rate of antibacterial drugs was 50.0%. The main medication maintaining time of antibacterial drugs were 48 and 72 h, accounting for 50.0% and 39.5%, respectively. There were nine breeds, in which cefuroxime, metronidazole, and cefoxitin were ranked the top three. The most time administration of antibacterial drugs was 0.5-1.0 h, accounting for 77.3%. The main types of unreasonable medicine were the non-strict mastering indications of the medication indication (31.4%), prolonged medication duration (28.7%), and inappropriate choice of medicine (17.6%). Conclusion The use of prophylactic antibacterial drugs in gynecological aseptic operations in Women and Infants Hospital of Zhengzhou is basically rational. But there are still some irrational usages of antibacterial drugs, and they needs further efforts to strengthen the management.

常州四药临床药学科研基金项目（CZSYJJ15018）