目的 了解武汉大学人民医院抗精神病药物的使用情况，为医护人员提供参考。方法 选取武汉大学人民医院2014年9月-2016年9月154份脑器质性精神病患者病历进行回顾性分析，对患者的性别、年龄、病因、用药方案、抗精神病药物的使用情况以及不良反应进行分类统计。结果 154例脑器质性精神病患者中，男性多于女性；年龄多是大于40岁的中老年患者；病因复杂，多集中在脑血管疾病、脑萎缩、脑白质病3大原因；精神病表现综合征主要为精神病性症状，脑器质性精神病治疗方案多采用精神药物联用的方案，且奥氮平是临床上最常用的脑器质性精神病的治疗药物。结论 从药物流行病学角度考察了武汉大学人民医院脑器质性精神病的药物利用模式，对临床制订抗精神病药物治疗方案有积极意义。

Objective To realize the utilization of antipsychotic drugs in Renmin Hospital of Wuhan University, in order to provide a reference for medical staff. Methods Records of 154 patients with brain organic mental disorder in Renmin Hospital of Wuhan University from September 2014 to September 2016 were analyzed. Gender, age, etiology, drug programs, utilization of antipsychotic drugs, and drug adverse reactions were classified statistically. Results In patients (154 cases) with brain organic mental disorders, men were more than women, and patients above 40 years old were more focused. Etiology was complex, and more were focused on cerebrovascular diseases, cerebral atrophy, and leukoencephalopathy. Psychotic symptoms were the main form of organic mental disorder. Most patients with brain organic mental disorder used more than one antipsychotic drug. Additionally, olanzapine was the most common administrated drug in the hospital. Conclusion The drug utilization pattern of antipsychotics in Renmin Hospital of Wuhan University is discussed in the view of drug epidemiology, and it may have positive meaning for clinic to make antipsychotic medication for organic mental disorders.