目的 观察雷尼替丁联合西地碘含片治疗复发性阿弗他溃疡的临床疗效。方法 选取2013年8月-2015年7月罗田县万密斋医院口腔科收治的复发性阿弗他溃疡患者124例，按照入选次序编号并分为对照组和治疗组，每组各62例。对照组口含西地碘含片，1片/次，5次/d。治疗组在对照组治疗的基础上，取盐酸雷尼替丁胶囊研磨成粉末，用消毒棉签将其涂敷于溃疡面上，1粒/次，4次/d，直至溃疡消失，黏膜修复完全为止。观察两组的临床疗效，同时比较两组患者疼痛指数和平均溃疡期。结果 治疗后，对照组和治疗组的总有效率分别为80.65%、95.16%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者疼痛指数均较治疗前显著降低，同组治疗前后差异有统计学意义（P<0.05）；治疗后治疗组疼痛指数低于对照组，两组比较差异有统计学意义（P<0.05）。治疗组患者的平均溃疡期短于对照组，两组比较差异有统计学意义（P<0.05）。结论 雷尼替丁联合西地碘含片治疗口腔溃疡具有较好的临床疗效，可降低疼痛指数，缩短平均溃疡期，具有一定的临床推广应用价值。

Objective To explore the clinical efficacy of ranitidine combined with Cydiodine Buccal Tablets in treatment of recurrent aphthous ulcer. Methods The total of 124 patients with recurrent aphthous ulcer in Wanmizhai Hospital in Luotian County from August 2013 to July 2015 were analyzed. The patients were divided into control group and treatment group according to the selected order numbers, and each group had 62 cases. The patients in the control group held Cydiodine Buccal Tablets in the mouth, 1 tablet/time, five times daily. Ranitidine Hydrochloride Capsules were grounded into powder, and coated on the ulcer surface with disinfection swab in the treatment group on the basis of the control group, 1 grain/time, four times daily. Two groups were treated until ulcer disappeared and mucosal repaired completely. After treatment, the efficacy was evaluated, and pain indexes and average ulcer stage in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 80.65% and 95.16%, respectively, and there were differences between two groups (P<0.05). After treatment, pain indexes in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, pain indexes in the treatment group were lower than that in the control group, with significant difference between two groups (P<0.05). The average ulcer stage in the treatment group was shorter than that in the control group, with significant difference between two groups (P<0.05). Conclusion Ranitidine combined with Cydiodine Buccal Tablets has clinical curative effect in treatment of recurrent aphthous ulcer, and can reduce the pain index, also can shorten the average ulcer stage, which has a certain clinical application value.