目的 探讨丹鳖胶囊联合甲睾酮片和米非司酮治疗子宫肌瘤的临床疗效。方法 选取2015年6月-2016年6月在监利县人民医院进行治疗的子宫肌瘤患者82例，根据治疗方案的差别分为对照组（41例）和治疗组（41例）。对照组患者口服甲睾酮片，1片/次，1次/d；同时口服米非司酮片，1片/次，1次/d。治疗组在对照组的基础上口服丹鳖胶囊，5粒/次，3次/d，两组患者均连续治疗3个月经周期。观察两组患者的临床疗效，同时比较两组患者治疗前后性激素水平和血清细胞因子水平改变。结果 治疗后，对照组的总有效率为80.49%，显著低于治疗组的95.12%，两组总有效率比较差异具有统计学意义（P<0.05）。治疗后，两组患者雌二醇（E₂）、孕酮（P）、促卵泡素（FSH）和促黄体素（LH）水平均明显降低，同组治疗前后差异具有统计学意义（P<0.05）；且治疗组上述指标降低程度优于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者血清白细胞介素-2（IL-2）水平升高，肿瘤坏死因子-α（TNF-α）水平则降低，同组治疗前后差异具有统计学意义（P<0.05）；且治疗组这些指标明显优于对照组，两组比较差异有统计学意义（P<0.05）。结论 丹鳖胶囊联合甲睾酮片和米非司酮治疗子宫肌瘤的效果显著，改善性激素水平，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Danbie Capsules combined with methyltestosterone and mifepristone in treatment of uterine fibroids. Methods Patients (82 cases) with uterine fibroids in Jianli People's Hospital from June 2015 to June 2016 were divided into control group (41 cases) and treatment group (41 cases) according to different treatments. Patients in the control group were po administered with Methyltestosterone Tablets, 1 tablet/time, once daily. And they were also po administered with Mifepristone Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Danbie Capsules on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for three menstrual cycles. After treatment, the clinical efficacy was evaluated, sex hormone level and serum cytokine level in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.49%, which was significantly lower than 95.12% in the treatment group, and there were differences between two groups (P<0.05). After treatment, E₂, P, FSH, and LH level in two groups was significantly decreased, the difference was statistically significant in the same group (P<0.05). And the decrease degree of these indicators in the treatment group was significantly better than that in the control group, with significant difference between two groups (P<0.05). After treatment, the IL-2 level in two groups was significantly increased, but TNF-α level was significantly decreased, the difference was statistically significant in the same group (P<0.05). And the two indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Danbie Capsules combined with Methyltestosterone Tablets and mifepristone has a significant clinical effect in treatment of uterine fibroids, and improve sex hormones, which has a certain clinical application value.