目的 探讨唑来膦酸注射液联合碳酸钙D₃片治疗老年女性骨质疏松的临床疗效。方法 选取2014年6月-2015年8月在保定市第一中心医院治疗的老年女性骨质疏松患者110例，所有患者随机分为对照组和治疗组，每组各55例。对照组口服碳酸钙D₃片，2片/次，1次/d。治疗组在对照组基础上静脉滴注唑来膦酸注射液，4 mg加入到0.9%氯化钠溶液100mL中，1次/年。两组患者均治疗1年。观察两组的临床疗效，比较两组的骨密度、骨代谢指标和VAS评分情况。结果 治疗后，对照组和治疗组的总有效率分别为74.5%、90.9%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者腰椎骨、股骨颈和Ward's三角区骨密度均明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的升高程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组碱性磷酸酶（ALP）的水平明显下降，治疗组钙（Ca）、磷（P）和降钙素（HCT）水平明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组VAS评分均明显下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组VAS评分低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 唑来膦酸注射液联合碳酸钙D₃片治疗老年女性骨质疏松具有较好的临床疗效，能增加患者骨密度，调节骨代谢指标，减少疼痛程度，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Zoledronic Acid Injection combined with Calcium Carbonate and Vitamin D₃ Tablets in treatment of osteoporosis in old women. Methods Elderly female patients (110 cases) with osteoporosis in the First Central Hospital of Baoding from June 2014 to August 2015 were randomly divided into control and treatment groups, and each group had 55 cases. Patients in the control group were po administered with Calcium Carbonate and Vitamin D₃ Tablets, 2 tablets/time, once daily. Patients in the treatment group were iv administered with Zoledronic Acid Injection on the basis of the control group, 4 mg added into normal saline 100 mL, once yearly. Patients in two groups were treated for one year. After treatment, the clinical efficacies were evaluated, and bone density, bone metabolism indexes, and VAS scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 74.5% and 90.9%, respectively, and there was difference between two groups (P<0.05). After treatment, the bone density of lumbar spine, femoral neck, and Ward's Triangle in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of ALP in two groups were significantly decreased, but the levels of Ca, P, and HCT in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the VAS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the VAS score in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Zoledronic Acid Injection combined with Calcium Carbonate and Vitamin D₃ Tablets has clinical curative effect in treatment of osteoporosis in old women, can increase bone density, regulate bone metabolism index, and reduce the pains, which has a certain clinical application value.