目的 比较托莫西汀和阿立哌唑治疗儿童注意缺陷多动障碍的临床疗效。方法 收集2015年1月-2016年1月在大连市第七人民医院诊治的88例注意缺陷多动障碍患者，根据用药方案的不同分为对照组和治疗组，每组各44例。对照组患儿口服阿立哌唑片，1片/次，每晚1次。治疗组患儿口服盐酸托莫西汀胶囊，初始剂量为每天0.5 mg/kg，治疗过程中根据临床反应及耐药性进行剂量调整，每天最大剂量为1.4 mg/kg。两组患儿均连续治疗6周。比较两组患儿临床效果、SNAP-IV量表评分、数字划消失误率和Conners父母量表测验结果。结果 治疗后，对照组和治疗组的总有效率分别为81.82%、97.73%，两组总有效率比较差异具有统计学意义（P<0.05）。治疗后，两组患儿SNAP-IV量表评分、数字划消失误率和Conners父母量表测验结果均显著改善，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗后治疗组患儿上述观察指标比对照组的改善更明显，两组比较差异有统计学意义（P<0.05）。结论 托莫西汀治疗注意缺陷多动障碍临床效果显著，有利于患者认知功能的改善，具有一定的临床推广应用价值。

Objective To compare the clinical efficacy of aripiprazole and atomoxetine in treatment of children with attention deficit hyperactivity disorder. Methods Children (88 cases) with attention deficit hyperactivity disorder in Dalian Seventh People's Hospital from January 2015 to January 2016 were divided into control and treatment groups based on different treatments, and each group had 44 cases. Children in the control group were po administered with Aripiprazole Tablets, 1 tablet/time, once per night. Children in the treatment group were po administered with Atomoxetine Hydrochloride Capsules., The initial dosage was 0.5 mg/kg daily, and which was adjusted according to clinical response and drug resistance, and the maximum dosage was 1.4 mg/kg daily. Children in two groups were treated for 6 weeks. After treatment, the clinical efficacy, SNAP-IV scores, digital cancellation error rate, and Conners parents scale Results in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.40% and 95.35%, respectively, and there was difference between two groups (P<0.05). After treatment, SNAP-IV scores, digital cancellation error rate, and Conners parents scale Results in two groups were significantly improved, and the difference was statistically significant in the same group (P<0.05). And these indicators in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Atomoxetine has a significant clinical effect in treatment of children with attention deficit hyperactivity disorder, which is conducive to improve the cognitive function, and has a certain clinical application value.