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目的 探讨单磷酸阿糖腺苷联合布地奈德治疗小儿毛细支气管炎的临床疗效。方法 选取2014年9月-2016年9月沈阳医学院附属中心医院儿科收治的毛细支气管炎患者151例,随机分成对照组(75例)和治疗组(76例)。对照组雾化吸入吸入用布地奈德混悬液,0.5 mg加入生理盐水3 mL,1次/d,10 min/次。治疗组在对照组的基础上静脉滴注注射用单磷酸阿糖腺苷,0.1 g加入5%葡萄糖溶液100 mL中,1次/d。所有患者均治疗1周。观察两组患者临床效果,对比两组治疗前后症状消失时间、住院时间、炎性指标以及不良反应情况。结果 治疗后,对照组和治疗组总有效率分别为84.00%和96.05%,两组总有效率比较差异具有统计学意义(P<0.05)。治疗后,治疗组患儿的退热时间、湿啰音消失时间、喘息消失时间和咳嗽消失时间以及住院时间均明显短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患儿肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)以及IL-8指标均明显降低(P<0.05);且治疗组的降低程度明显优于对照组,两组比较差异有统计学意义(P<0.05)。结论 单磷酸阿糖腺苷联合布地奈德治疗小儿毛细支气管炎,在临床症状消失时间、住院时间以及炎症因子水平改善方面上均优于单独使用布地奈德治疗,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effect of clinical study on vidarabine monophosphate combined with budesonide in treatment of children with bronchiolitis. Methods Children (151 cases) with bronchiolitis in Central Hospital Affiliated to Shenyang Medical College from September 2014 to September 2016 were divided into control group (75 cases) and treatment group (76 cases). Children in the control group were aerosol inhalation administered with Budesonide Suspension for inhalation, 0.5 mg added into normal saline 3 mL, once daily, 10 min/time. Patients in the treatment group were iv administered with Vidarabine Monophosphate for injection on the basis of the control group, 0.1 g added into 5% glucose solution 100 mL, once daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, symptom disappearance time, hospitalization time, inflammatory indexes, and incidence of adverse reactions in two groups before and after treatment was compared. Results After treatment, the clinical efficacies in the control and treatment groups were 84.00% and 96.05%, respectively, and there was difference between two groups (P<0.05). After treatment, pyretolysis time, the disappearance time of lung wet rales, wheezing, and cough, and hospitalization time in treatment group were significantly shorter than those in the control group, with significant difference between two groups (P<0.05). After treatment, TNF-α, IL-6, and IL-8 in two groups was significantly decreased (P<0.05). And the decrease degree of these indicators in the treatment group was significantly better than that in the control group, with significant difference between two groups (P<0.05). Conclusion Adenosine monophosphate combined with budesonide has clinical curative effect in treatment of children with bronchiolitis, especially on the disappearance time of clinical symptoms, hospitalization time improvement, and inflammatory factor, which has a certain clinical application value.
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